今日の臨床サポート 今日の臨床サポート

著者: 水関隆也 広島県立総合リハビリテーションセンター

監修: 竹下克志 自治医科大学整形外科

著者校正/監修レビュー済:2025/05/14
参考ガイドライン:
  1. 日本リウマチ学会:関節リウマチ診療ガイドライン2024改訂
患者向け説明資料

改訂のポイント:
  1. 『関節リウマチ診療ガイドライン2024改訂』を参照に、以下について加筆・修正した。
  1. 人工肘関節形成術では、手術手技、後療法に習熟した施設、術者によって行われることが望ましい。

概要・推奨   

  1. 投薬治療抵抗性のリウマチ肘では関節破壊が軽度の場合、滑膜切除術が勧められる(推奨度2)
  1. 関節破壊が高度の場合、人工肘関節形成術が勧められる(推奨度3)。ただし、手術手技、後療法に習熟した施設、術者によって行われることが望ましい。

病態・疫学・診察 

疾患情報(疫学・病態)  
  1. リウマチ肘は全身的な関節リウマチの一関節炎として肘関節に出現する。肘関節の腫脹、疼痛、運動障害が一般的であるが症状が進行すれば強直、変形、不安定性もみられる。
  1. 関節リウマチにより肘関節内の滑膜が炎症を起こすと、関節液が増加し関節は腫脹する。
  1. 放置されると関節軟骨が浸食され、軟骨下骨が露出される。随所にパンヌスが形成され、関節破壊が進行することとなる。
  1. 関節破壊が進行すると、関節裂隙の狭小化を来したり、逆に不安定性が増加したりさまざまなX線像を呈する。
  1. 臨床的には痛みは必発であるが、可動域が制限される場合と、不安定ながら維持される場合がある。
  1. 生物学的製剤の治療への導入により最近は肘関節炎に遭遇する機会が少なくなった。
問診・診察のポイント  
問診:
  1. 全身的に関節リウマチの合併を確認する。

これより先の閲覧には個人契約のトライアルまたはお申込みが必要です。

最新のエビデンスに基づいた二次文献データベース「今日の臨床サポート」。
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文献 

Horiuchi K, Momohara S, Tomatsu T, Inoue K, Toyama Y.
Arthroscopic synovectomy of the elbow in rheumatoid arthritis.
J Bone Joint Surg Am. 2002 Mar;84(3):342-7. doi: 10.2106/00004623-200203000-00002.
Abstract/Text BACKGROUND: The purpose of this study was to investigate the results of arthroscopic synovectomy for the treatment of elbows affected by rheumatoid arthritis.
METHODS: Arthroscopic synovectomy was performed on twenty-nine elbows (twenty-seven patients) between 1984 and 1996. Twenty-one elbows (twenty patients), followed for a minimum of forty-two months, were evaluated clinically with use of the Mayo elbow performance score and radiographic findings. The mean duration of follow-up was ninety-seven months. With use of the system of Larsen et al., we classified all elbows into three groups--Grades 1 and 2, Grade 3, and Grade 4--according to the preoperative radiographic findings. These groups were then compared.
RESULTS: The mean Mayo elbow performance score improved from 48.3 points preoperatively to 77.5 points (an excellent result in two elbows, a good result in thirteen, a fair result in six, and a poor result in none) at two years after the operation and 69.8 points (an excellent result in two elbows, a good result in seven, a fair result in seven, and a poor result in five) at the final follow-up evaluation. The mean score for pain improved from 9.3 points preoperatively to 31.4 points at two years after the operation and 27.9 points at the final follow-up evaluation. Clinically apparent synovitis recurred in five of the twenty-one elbows, and two of the five required total elbow arthroplasty. Among the three groups, only elbows with Larsen Grade-1 or 2 arthritis had a favorable long-term result with regard to total function. The postoperative results were unsatisfactory for Larsen Grade-4 elbows.
CONCLUSIONS: Arthroscopic synovectomy in an elbow affected by rheumatoid arthritis is a reliable procedure that can alleviate pain. Our results suggest that one of the most favorable indications for arthroscopic synovectomy is a preoperative radiographic rating of Grade 1 or 2.

PMID 11886901
Tanaka N, Sakahashi H, Hirose K, Ishima T, Ishii S.
Arthroscopic and open synovectomy of the elbow in rheumatoid arthritis.
J Bone Joint Surg Am. 2006 Mar;88(3):521-5. doi: 10.2106/JBJS.E.00472.
Abstract/Text BACKGROUND: Synovectomy has been advocated for early treatment of the rheumatoid elbow. It has not been determined whether arthroscopic or open synovectomy is better and whether a preoperative arc of flexion of >90 degrees is an important prognostic factor.
METHODS: Arthroscopic or open synovectomy was performed in fifty-eight elbows in fifty-three patients with rheumatoid arthritis and radiographic changes in the joint of Larsen grade 2 or less. Clinical symptoms, recurrent synovitis, postoperative complications, and radiographic changes were assessed ten to eighteen years (average, thirteen years) postoperatively.
RESULTS: Eleven (48%) of twenty-three elbows in which arthroscopic synovectomy had been performed and sixteen (70%) of twenty-three elbows in which open synovectomy had been performed were mildly or not painful at the latest follow-up evaluation. However, no significant difference was detected between the overall clinical results of arthroscopic synovectomy and those of open synovectomy. In elbows with a preoperative arc of flexion of <90 degrees , the clinical results of the two procedures were comparable. In elbows with a preoperative arc of flexion of <90 degrees , arthroscopic synovectomy provided significantly (p < 0.05) better function than open surgery after mid-term follow-up, and motion and function continued to be better in those patients at the most recent follow-up evaluation. Recurrent synovitis was observed in six elbows that had arthroscopic synovectomy and in three that had open synovectomy, and the Larsen grade increased in both groups. Three elbows with a preoperative arc of flexion of <90 degrees underwent a total elbow arthroplasty to treat ankylosis after open synovectomy. Surgical complications were uncommon and not severe.
CONCLUSIONS: Arthroscopic synovectomy of the elbow is a reliable procedure. One of the most favorable indications for either arthroscopic or open synovectomy is a preoperative arc of elbow flexion of >/=90 degrees in patients with early rheumatoid arthritis.

PMID 16510817
水関隆也, 市川誠, 中前敦雄ほか:肘関節滑膜切除術の適応 どこまで可能か.日本肘関節研究会雑誌,10:1-2,2003..
水関 隆也, 増田 哲鈴木 修. K now TEAの中期成績. 日本肘関節学会雑誌. 2019;26(1):S139.
Qureshi F, Draviaraj KP, Stanley D.
The Kudo 5 total elbow replacement in the treatment of the rheumatoid elbow: results at a minimum of ten years.
J Bone Joint Surg Br. 2010 Oct;92(10):1416-21. doi: 10.1302/0301-620X.92B10.22476.
Abstract/Text Between September 1993 and September 1996, we performed 34 Kudo 5 total elbow replacements in 31 rheumatoid patients. All 22 surviving patients were reviewed at a mean of 11.9 years (10 to 14). Their mean age was 56 years (37 to 78) at the time of operation. All had Larsen grade IV or V rheumatoid changes on X-ray. Nine (three bilateral replacements and six unilateral) had died from unrelated causes. One who had died before ten years underwent revision for dislocation. Of the 22 total elbow replacements reviewed six had required revision, four for aseptic loosening (one humeral and three ulnar) and two for infection. Post-operatively, one patient had neuropraxia of the ulnar nerve and one of the radial nerve. Two patients had valgus tilting of the ulnar component. With revision as the endpoint, the mean survival time for the prosthesis was 11.3 years (95% confidence interval (10 to 13) and the estimated survival of the prosthesis at 12 years according to Kaplan-Meier survival analysis was 74% (95% confidence interval 0.53 to 0.91). Of the 16 surviving implants, ten were free from pain, four had mild pain and two moderate. The mean arc of flexion/extension of the elbow was 106° (65° to 130°) with pronation/supination of 90° (30° to 150°) with the joint at 90° of flexion. The mean Mayo elbow performance score was 82 (60 to 100) with five excellent, ten good and one fair result. Good long-term results can be expected using the Kudo 5 total elbow replacement in patients with rheumatoid disease, with a low incidence of loosening of the components.

PMID 20884981
Kodama A, Mizuseki T, Adachi N.
Kudo type-5 total elbow arthroplasty for patients with rheumatoid arthritis: a minimum ten-year follow-up study.
Bone Joint J. 2017 Jun;99-B(6):818-823. doi: 10.1302/0301-620X.99B6.BJJ-2016-1033.R2.
Abstract/Text AIMS: We assessed the long-term (more than ten-year) outcomes of the Kudo type-5 elbow prosthesis in patients with rheumatoid arthritis (RA).
MATERIALS AND METHODS: We reviewed 41 elbows (Larsen Grade IV, n = 21; Grade V, n = 20) in 31 patients with RA who had undergone a Kudo type-5 total elbow arthroplasty (TEA) between 1994 and 2003, and had been followed up for more than ten years. The humeral component was cementless and the all-polyethylene ulnar component cemented in every patient. Clinical outcome was assessed using the Mayo elbow performance score. We calculated the revision rate and evaluated potential risk factors for revision. The duration of follow-up was a mean 141 months (120 to 203).
RESULTS: Aseptic loosening of the ulnar component occurred in 11 elbows. There was no radiolucency around any humeral component. There was one deep infection. The survival rate according to Kaplan-Meier survivorship analysis was 87.8% after five years and 70.7% after ten years. The range of extension/flexion was a mean -38° (-80° to 0°)/105° (30° to 150°) before surgery and -40° (-70° to -20°)/132° (100° to 150°) at the final follow-up, while the mean Mayo elbow performance score was 43 before surgery and 80 at final follow-up. Disease duration of RA up to the TEA of < 15 years and a pre-operative range of movement (ROM) of > 85° were significant risk factors for revision or aseptic loosening.
CONCLUSION: Although Kudo type-5 prostheses gave satisfactory results in the short-term, aseptic loosening increased after five years. In most cases, elbow function was maintained in the long-term without loosening of the implant. A short duration from the onset of RA to TEA and a large pre-operative ROM were significant risk factors for revision or aseptic loosening. Cite this article: Bone Joint J 2017;99-B:818-23.

©2017 The British Editorial Society of Bone & Joint Surgery.
PMID 28566403
Aldridge JM 3rd, Lightdale NR, Mallon WJ, Coonrad RW.
Total elbow arthroplasty with the Coonrad/Coonrad-Morrey prosthesis. A 10- to 31-year survival analysis.
J Bone Joint Surg Br. 2006 Apr;88(4):509-14. doi: 10.1302/0301-620X.88B4.17095.
Abstract/Text There have been few reports in the literature of total elbow arthroplasty extending beyond 10 to 15 years. We reviewed 40 patients (41 elbows) with a mean age of 56 years (19 to 83) who had undergone a Coonrad/Coonrad-Morrey elbow arthroplasty by one surgeon for various diagnoses between 1974 and 1994. Surgical selection excluded patients with previous elbow infection or who refused to accept a sedentary level of elbow activity postoperatively. Objective data were collected from charts, radiographs, clinical photographs and supplemented by the referring orthopaedic surgeons' records and radiographs if health or distance prevented a patient from returning for final review. Subjective outcome was defined by patient satisfaction. Of the 41 elbows, 21 were functional between 10 and 14 years after operation, ten between 15 and 19 years and ten between 20 and 31 years. There were 14 complications and 13 revisions, but no cases of acute infection, or permanent removal of any implant.

PMID 16567787
薬剤監修について:
オーダー内の薬剤用量は日本医科大学付属病院 薬剤部 部長 伊勢雄也 以下、渡邉裕次、井ノ口岳洋、梅田将光および日本医科大学多摩永山病院 副薬剤部長 林太祐による疑義照会のプロセスを実施、疑義照会の対象については著者の方による再確認を実施しております。
※薬剤中分類、用法、同効薬、診療報酬は、エルゼビアが独自に作成した薬剤情報であり、 著者により作成された情報ではありません。
尚、用法は添付文書より、同効薬は、薬剤師監修のもとで作成しております。
※同効薬・小児・妊娠および授乳中の注意事項等は、海外の情報も掲載しており、日本の医療事情に適応しない場合があります。
※薬剤情報の(適外/適内/⽤量内/⽤量外/㊜)等の表記は、エルゼビアジャパン編集部によって記載日時にレセプトチェックソフトなどで確認し作成しております。ただし、これらの記載は、実際の保険適応の査定において保険適応及び保険適応外と判断されることを保証するものではありません。また、検査薬、輸液、血液製剤、全身麻酔薬、抗癌剤等の薬剤は保険適応の記載の一部を割愛させていただいています。
(詳細はこちらを参照)
著者のCOI(Conflicts of Interest)開示:
水関隆也 : 特に申告事項無し[2025年]
監修:竹下克志 : 講演料(第一三共(株))[2025年]

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