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著者: Stephen E Wang, Primo N Lara, Angie Lee-Ow, Jeanne Reed, Lori R Wang, Patti Palmer, Joseph M Tuscano, Carol M Richman, Laurel Beckett, Ted Wun
雑誌名: Am J Hematol. 2002 Jul;70(3):191-4. doi: 10.1002/ajh.10119.
Abstract/Text
Non-hemolytic transfusion reactions (NHTR) occur in up to 30% of patients receiving platelet transfusions. Premedication with acetaminophen and diphenhydramine is a common strategy to prevent NHTR, but its efficacy has not been studied. In this prospective trial, transfusions in patients receiving pre-storage leukocyte-reduced single-donor apheresis platelets (SDP) were randomized to premedication with either acetaminophen 650 mg PO and diphenhydramine 25 mg IV, or placebo. Fifty-one patients received 98 transfusions. Thirteen patients had 15 NHTR: 15.4% (8/52) in the treatment arm and 15.2% (7/46) in the placebo arm. Premedication prior to transfusion of pre-storage leukocyte reduced SDP does not significantly lower the incidence of NHTR as compared to placebo.
Copyright 2002 Wiley-Liss, Inc.
PMID 12111764 Am J Hematol. 2002 Jul;70(3):191-4. doi: 10.1002/ajh.10119.
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