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著者: Kenneth Frumkin
雑誌名: Ann Emerg Med. 2013 Dec;62(6):616-626.e8. doi: 10.1016/j.annemergmed.2013.05.026. Epub 2013 Jul 3.
Abstract/Text
Life-threatening warfarin-associated hemorrhage is common, with a high mortality. In the United States, the most commonly used therapies--fresh frozen plasma and vitamin K--are slow and unpredictable and can result in volume overload. Outside of the United States, prothrombin complex concentrates are often used instead; these pooled plasma products reverse warfarin anticoagulation in minutes rather than hours. This article reviews the literature relating to warfarin reversal with fresh frozen plasma, prothrombin complex concentrates, and recombinant factor VIIa and provides elements for a management protocol based on this literature.
Copyright © 2013 American College of Emergency Physicians. Published by Mosby, Inc. All rights reserved.
PMID 23829955 Ann Emerg Med. 2013 Dec;62(6):616-626.e8. doi: 10.1016/j.annemergmed.2013.05.026. Epub 2013 Jul 3.
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