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著者: Nobuyuki Matsuhashi, Eiji Sakai, Ken Ohata, Norihisa Ishimura, Fujisaki Junko, Tomoki Shimizu, Katsunori Iijima, Tomoyuki Koike, Takao Endo, Takefumi Kikuchi, Tatsuya Inayoshi, Yuji Amano, Takahisa Furuta, Ken Haruma, Yoshikazu Kinoshita
雑誌名: J Gastroenterol Hepatol. 2016 Jul 15;. doi: 10.1111/jgh.13491. Epub 2016 Jul 15.
Abstract/Text
BACKGROUND AND AIM: The incidence of esophageal adenocarcinoma (EAC) in cases with long-segment Barrett esophagus (BE) has not been investigated in Japan. The aim of this study is to investigate the incidence of EAC in Japanese cases with long-segment BE prospectively.
METHODS: This is a multicenter prospective cohort study investigating the incidence rate of EAC in patients with BE with a length of at least 3 cm. Study subjects received index esophagogastroduodenoscopy at the time of enrollment, and they were instructed to undergo yearly follow-up esophagogastroduodenoscopy. Patients in whom EAC was diagnosed in the endoscopic examinations underwent subsequent treatment and their prognosis was observed.
RESULTS: Of 215 enrolled patients, six (2.8%) were initially diagnosed with EAC at the enrollment. Among the remaining 209 patients, 132 received at least one follow-up esophagogastroduodenoscopy. In this follow-up, three EACs developed in observed 251 patient-year (incidence rate; 1.2% per year). Most of the EACs detected at the initial endoscopic examination (5/6, 83%) were already at advanced stages. Meanwhile, all the three lesions detected in the follow-up esophagogastroduodenoscopies were identified as early cancers and underwent curative resection.
CONCLUSIONS: The incidence rate of EAC in Japanese cases with long-segment BE was calculated to be 1.2% in a year.
This article is protected by copyright. All rights reserved.
PMID 27416773 J Gastroenterol Hepatol. 2016 Jul 15;. doi: 10.1111/jgh.13491. Epub 2016 Jul 15.
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