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著者: Tetsuro Kusaba, Yusuke Konno, Shigeo Hatta, Tomoya Fujino, Takashi Yasuda, Hiroshi Miura, Hiroyo Sasaki, Jun Okabayashi, Mei Murao, Tsutomu Sakurada, Goro Imai, Sayuri Shirai, Shingo Kuboshima, Yoshinori Shima, Goichi Ogimoto, Takeo Sato, Keisou Masuhara, Kenjiro Kimura
雑誌名: Pharmacotherapy. 2005 Jan;25(1):52-8. doi: 10.1592/phco.25.1.52.55617.
Abstract/Text
STUDY OBJECTIVE: To compare the absorption profile of cyclosporine after preprandial administration with that after postprandial administration, and to determine which administration time resulted in a more stable absorption profile and the timing of the drug concentration that was the most reliable marker for monitoring drug absorption.
DESIGN: Prospective analysis.
SETTING: University teaching hospital in Japan.
PATIENTS: Sixteen patients with refractory nephrotic syndrome.
INTERVENTION: Thirteen patients received cyclosporine after breakfast (postprandial group) and eight received the drug 30 minutes before breakfast (preprandial group).
MEASUREMENTS AND MAIN RESULTS: Blood cyclosporine concentration was measured 5 times serially: before administration (C 0 ) and at 1-hour intervals until 4 hours after administration of cyclosporine (C 1 -C 4 ). Also, area under the concentration-time curve from 0-4 hours (AUC 0-4 ) was calculated. Of the 13 patients in the postprandial group, six (46%) showed fair absorption and exhibited a peak concentration at C 1 or C 2 (high-absorption pattern); seven (54%) showed poor absorption and did not reach the peak concentration within the 4-hour period (low-absorption pattern). Five of the seven patients with the low-absorption pattern were switched from postprandial to preprandial administration. All patients in the preprandial administration group showed a high-absorption pattern and reached the peak cyclosporine concentration at C 1 . The C 2 value showed the best correlation with AUC 0-4 in both groups, and the C 0 parameter did not correlate with AUC 0-4 in either group.
CONCLUSION: Preprandial administration provided a more stable absorption profile of cyclosporine compared with postprandial administration. From the correlation with AUC 0-4 , we concluded that C 2 , and not C 0 , is a reliable marker for monitoring cyclosporine exposure.
PMID 15767220 Pharmacotherapy. 2005 Jan;25(1):52-8. doi: 10.1592/phco.25.1.52.55617.
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