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著者: E Muso, M Mune, Y Fujii, E Imai, N Ueda, K Hatta, A Imada, T Takemura, S Miki, T Kuwahara, Y Takamitsu, Y Tsubakihara, Kansai FGS LDL Apheresis Treatment (K-FLAT) Study Group
雑誌名: Nephron. 2001 Dec;89(4):408-15.
Abstract/Text
Rapid amelioration of hypercholesterolemia by LDL apheresis (LDL-A) was performed for long-standing nephrotic syndrome (NS) with hyperlipidemia due to focal segmental glomerulosclerosis (FGS) and the clinical data and prognosis were compared between LDL-A-treated and nontreated groups. Seventeen steroid-resistant NS patients treated with LDL-A (LDL-A group) and 10 NS patients treated with steroids only (steroid-monotherapy (SM) group) were compared. Serum cholesterol and phospholipid levels were significantly lowered only in the LDL-A group (p < 0.01, respectively). The LDL-A group showed a significant decrease of urinary protein (UP, p < 0.01) and increase of serum albumin (p < 0.05). Average time needed to achieve a decrease of UP to less than nephrotic range (< 3.5 g/day) was significantly shorter in the LDL-A group than in the SM group (p < 0.01). Although this is not a prospective study, it is highly expected that a rapid improvement of hypercholesterolemia by LDL-A in steroid-resistant NS will provide more rapid relief from NS than steroid therapy alone.
Copyright 2001 S. Karger AG, Basel
PMID 11721158 Nephron. 2001 Dec;89(4):408-15.
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