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著者: Hitoshi Ando, Shuichi Tsuruoka, Hayato Yanagihara, Koh-ichi Sugimoto, Masaaki Miyata, Yasushi Yamazoe, Toshinari Takamura, Shuichi Kaneko, Akio Fujimura
雑誌名: Br J Clin Pharmacol. 2005 Nov;60(5):494-7. doi: 10.1111/j.1365-2125.2005.02462.x.
Abstract/Text
AIMS: To compare the effects of grapefruit juice (GFJ) on the pharmacokinetics of pitavastatin and atorvastatin.
METHODS: In a randomized, four-phase crossover study, eight healthy subjects consumed either GFJ or water t.i.d. for 4 days in each trial. On each final day, a single dose of 4 mg pitavastatin or 20 mg atorvastatin was administered.
RESULTS: GFJ increased the mean AUC(0-24) of atorvastatin acid by 83% (95% CI 23-144%) and that of pitavastatin acid by 13% (-3 to 29%).
CONCLUSIONS: Pitavastatin, unlike atorvastatin, appears to be scarcely affected by the CYP3A4-mediated metabolism.
PMID 16236039 Br J Clin Pharmacol. 2005 Nov;60(5):494-7. doi: 10.1111/j.1365-2125.2005.02462.x.
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