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抗癌剤による味覚障害に対する治療

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		11:	[Cevimeline hydrochloride hydrate (Saligren capsule 30 mg): a review of its pharmacological profiles and clinical potential in xerostomia].
			著者: Akira Shiozawa 雑誌名: Nihon Yakurigaku Zasshi. 2002 Oct;120(4):253-8. Abstract/Text Cevimeline hydrochloride hydrate is a muscarinic receptor agonist with a chemical structure of a quinuclidine. Intraduodenal administration of cevimeline hydrochloride hydrate dose-dependently increased salivary secretion in normal mice and rats, two strains of autoimmune disease mice, and X-irradiated rats. The clinical efficacy of the cevimeline hydrochlide hydrate at 30 mg t.i.d. during 4 weeks has been demonstrated in double blind comparative study with placebo. In addition, its treatments in 52 weeks have increased salivary flow and improved subjective and objective symptoms of patients with xerostomia in Sjögren's syndrome. PMID 12425151 Nihon Yakurigaku Zasshi. 2002 Oct;120(4):253-8.