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著者: G Lina, Y Piémont, F Godail-Gamot, M Bes, M O Peter, V Gauduchon, F Vandenesch, J Etienne
雑誌名: Clin Infect Dis. 1999 Nov;29(5):1128-32. doi: 10.1086/313461.
Abstract/Text
Panton-Valentine leukocidin (PVL) is a cytotoxin that causes leukocyte destruction and tissue necrosis. It is produced by fewer than 5% of Staphylococcus aureus strains. A collection of 172 S. aureus strains were screened for PVL genes by polymerase chain reaction amplification. PVL genes were detected in 93% of strains associated with furunculosis and in 85% of those associated with severe necrotic hemorrhagic pneumonia (all community-acquired). They were detected in 55% of cellulitis strains, 50% of cutaneous abscess strains, 23% of osteomyelitis strains, and 13% of finger-pulp-infection strains. PVL genes were not detected in strains responsible for other infections, such as infective endocarditis, mediastinitis, hospital-acquired pneumonia, urinary tract infection, and enterocolitis, or in those associated with toxic-shock syndrome. It thus appears that PVL is mainly associated with necrotic lesions involving the skin or mucosa.
PMID 10524952 Clin Infect Dis. 1999 Nov;29(5):1128-32. doi: 10.1086/313461.
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