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著者: Nathalie Lassau, Michele Lamuraglia, Serge Koscielny, Alain Spatz, Alain Roche, Jerome Leclere, Marie-Françoise Avril
雑誌名: Cancer Imaging. 2006 Apr 25;6:24-9. doi: 10.1102/1470-7330.2006.0009. Epub 2006 Apr 25.
Abstract/Text
OBJECTIVE: To study the value of high-frequency sonography (HFS) and colour Doppler sonography (CDS) in evaluating the 5 year metastatic potential of primary cutaneous melanomas (CM).
MATERIALS AND METHODS: 111 CM were studied before surgical resection and 107 were depicted on HFS. The maximal HFS thickness was measured and compared with the Breslow thickness. A CDS study was performed in each tumour.
RESULTS: HFS thickness ranged from 0.26 to 8.0 mm and Breslow thickness from 0.15 to 8.0 mm. HFS and Breslow thickness correlated strongly (r > 0.93). Intratumour vessels were depicted in 43 of the 107 CM, of which 40 were thicker than 2 mm. The median follow-up was 61 months and 27 patients developed relapses. In the univariate analyses, neovascularization visualized with CDS, sonographic thickness and the Breslow thickness were significantly linked to relapses (p < 0.0001), as were lymph node status and ulceration (p = 0.007 and 0.004).
CONCLUSION: Vascularization was observed mainly in thick primary melanoma. A median follow-up of 5 years showed the prognostic value of angiogenesis evaluated by CDS.
PMID 16644502 Cancer Imaging. 2006 Apr 25;6:24-9. doi: 10.1102/1470-7330.2006.0009. Epub 2006 Apr 25.
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