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著者: Durga Paudel, Masafumi Utsunomiya, Koki Yoshida, Sarita Giri, Osamu Uehara, Hirofumi Matsuoka, Itsuo Chiba, Akira Toyofuku, Yoshihiro Abiko
雑誌名: Oral Dis. 2020 Jan;26(1):193-199. doi: 10.1111/odi.13226. Epub 2019 Nov 26.
Abstract/Text
OBJECTIVE: Burning mouth syndrome (BMS) is a chronic intraoral burning sensation with no identifiable causes. In this study, we aim to demonstrate the effectiveness of treatment strategy using ethyl loflazepate monotherapy or in combination with milnacipran or amitriptyline.
METHOD: A hospital-based, retrospective study was conducted in 86 patients. The patients were divided into remission group and non-remission group. The remission group comprised patients who were satisfied with their pain relief within a year of treatment initiation and did not require any follow-up treatment. The treatment was considered effective if the patient got remission within 1 year or was able to reduce the visual analogue scale (VAS) score to <20, in the absence of remission.
RESULTS: The treatment strategy was effective in 76.7% of the patients. Significant reductions (p < .05) in VAS scores from 73.5 ± 14.2 at first visit to 14.7 ± 8.7 at last visit in the remission group, and from 79.7 ± 14.3 at first visit to 33.4 ± 23.7 after 1 year of treatment in the non-remission group were noted.
CONCLUSION: The treatment strategy using ethyl loflazepate monotherapy or in combination with milnacipran or amitriptyline can be very effective in reducing pain in BMS patients.
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.
PMID 31705718 Oral Dis. 2020 Jan;26(1):193-199. doi: 10.1111/odi.13226. Epub 2019 Nov 26.
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