| |
著者: G De Serres, N Boulianne, B Duval
雑誌名: Pediatr Infect Dis J. 1995 Nov;14(11):969-75. doi: 10.1097/00006454-199511000-00009.
Abstract/Text
To evaluate the field effectiveness of erythromycin prophylaxis for pertussis within families, a retrospective cohort study was conducted among 246 families. Overall 41% of the subjects (387 of 940) had been sick. The secondary attack rate was 65% for infants younger than 2 years, 54% for those 2 to 4 years old and 39% for children 5 to 9 years old, and it declined thereafter. The secondary attack rate decreased from 25% in families without prophylaxis to 17% in families with prophylaxis. The protection induced by prophylaxis did not vary with age or vaccination status. When prophylaxis was used before the onset of a secondary case, the secondary attack rate was 4% compared with 35% when given after a secondary case (P < 0.001). Erythromycin prophylaxis seems to be efficient in preventing secondary cases but is most useful when administered before the occurrence of the first secondary case.
PMID 8584364 Pediatr Infect Dis J. 1995 Nov;14(11):969-75. doi: 10.1097/00006454-199511000-00009.
|
