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著者: Marco Zaffanello, Vassilios Fanos
雑誌名: Pediatr Nephrol. 2009 Oct;24(10):1901-11. doi: 10.1007/s00467-008-1066-9. Epub 2008 Dec 9.
Abstract/Text
Considerable concern has been expressed on the importance of identifying an improved therapeutic protocol for use in the treatment of childhood Henoch-Schönlein purpura nephritis, primarily due to the unpredictable success shown to date in improving long-term renal outcome. This review focuses on published reports describing the outcomes of therapeutic approaches currently being used in the treatment of pediatric Henoch-Schönlein purpura nephritis, with the aim of providing information that will facilitate a treatment-based approach in children presenting with varying degrees of kidney disease. The conclusions of the authors of this review are that currently prescribed treatments of children affected by Henoch-Schönlein purpura nephritis are not adequately guided by evidence obtained in properly designed, randomized, placebo-controlled trials with outcome markers related to the progression to end stage renal disease (level I evidence). Moreover, firm evidence supporting the best practice to be applied with the aim of delaying the progression of kidney disease is still lacking.
PMID 19066976 Pediatr Nephrol. 2009 Oct;24(10):1901-11. doi: 10.1007/s00467-008-1066-9. Epub 2008 Dec 9.
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