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著者: Stefano Bassetti, Werner E Bischoff, Mark Walter, Barbara A Bassetti-Wyss, Lori Mason, Beth A Reboussin, Ralph B D'Agostino, Jack M Gwaltney, Michael A Pfaller, Robert J Sherertz
雑誌名: Infect Control Hosp Epidemiol. 2005 Feb;26(2):196-203. doi: 10.1086/502526.
Abstract/Text
OBJECTIVE: To determine whether healthy adult nasal carriers of Staphylococcus aureus can disperse S. aureus into the air after rhinovirus infection.
DESIGN: We investigated the "cloud" phenomenon among adult nasal carriers of S. aureus experimentally infected with a rhinovirus. Eleven volunteers were studied for 16 days in an airtight chamber wearing street clothes, sterile garb, or sterile garb plus surgical mask; rhinovirus inoculation occurred on day 2. Daily quantitative air, nasal, and skin cultures for S. aureus; cold symptom assessment; and nasal rhinovirus cultures were performed.
SETTING: Wake Forest University School of Medicine, Winston-Salem, North Carolina.
PARTICIPANTS: Wake Forest University undergraduate or graduate students who had persistent nasal carriage of S. aureus for 4 or 8 weeks.
RESULTS: After rhinovirus inoculation, dispersal of S. aureus into the air increased 2-fold with peak increases up to 34-fold. Independent predictors of S. aureus dispersal included the time period after rhinovirus infection and wearing street clothes (P < .05). Wearing barrier garb but not a mask decreased dispersal of S. aureus into the air (P < .05).
CONCLUSION: Virus-induced dispersal of S. aureus into the air may have an important role in the transmission of S. aureus and other bacteria.
PMID 15756892 Infect Control Hosp Epidemiol. 2005 Feb;26(2):196-203. doi: 10.1086/502526.
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