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著者: Donald E Low
雑誌名: Crit Care Clin. 2013 Jul;29(3):651-75. doi: 10.1016/j.ccc.2013.03.012.
Abstract/Text
Toxic shock syndrome (TSS) is primarily the result of a superantigen-mediated cytokine storm and M protein-mediated neutrophil activation, resulting in the release of mediators leading to respiratory failure, vascular leakage, and shock. Mortality for streptococcal TSS still hovers at 50%. There is evidence to support a role for intravenous immunoglobulin (IVIG) in the treatment of streptococcal TSS. An observational study suggests that an initial conservative surgical approach combined with the use of immune modulators, such as IVIG, may reduce the morbidity associated with extensive surgical exploration in hemodynamically unstable patients without increasing mortality.
Copyright © 2013 Elsevier Inc. All rights reserved.
PMID 23830657 Crit Care Clin. 2013 Jul;29(3):651-75. doi: 10.1016/j.ccc.2013.03.012.
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