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著者: Paolo Vercellini, Edgardo Somigliana, Raffaella Daguati, Paola Vigano, Francesca Meroni, Pier Giorgio Crosignani
雑誌名: Am J Obstet Gynecol. 2008 May;198(5):504.e1-5. doi: 10.1016/j.ajog.2007.11.010. Epub 2008 Feb 1.
Abstract/Text
OBJECTIVE: The purpose of this study was to compare the postoperative risk of endometrioma recurrence in women using oral contraception and in those undergoing simple observation.
STUDY DESIGN: After laparoscopic excision of ovarian endometriotiomas, a cyclic, low-dose, monophasic oral contraceptive pill (OCP) was offered to women not seeking pregnancy. One month after surgery, and every 6 months afterward, the patients underwent clinical and ultrasonographic assessment.
RESULTS: Of the 277 patients who entered the study, 102 used OCP for the entire follow-up period (always users), 129 used OCP discontinuously (ever users), and 46 declined treatment (never users). The median follow-up was 28 months. Recurrent endometriotic cysts were detected in 74 subjects (27%). The 36-month cumulative proportion of subjects free from endometrioma recurrence was 94% in the always users compared with 51% in the never users (P < .001); adjusted incidence rate ratio (IRR) = 0.10 (95% CI, 0.04-0.24).
CONCLUSION: Regular postoperative use of OCP effectively prevents endometrioma recurrence.
PMID 18241819 Am J Obstet Gynecol. 2008 May;198(5):504.e1-5. doi: 10.1016/j.ajog.2007.11.010. Epub 2008 Feb 1.
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