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著者: Akihisa Takasaki, Hiroshi Tamura, Ken Taniguchi, Hiromi Asada, Toshiaki Taketani, Aki Matsuoka, Yoshiaki Yamagata, Katsunori Shimamura, Hitoshi Morioka, Norihiro Sugino
雑誌名: J Ovarian Res. 2009 Jan 14;2:1. doi: 10.1186/1757-2215-2-1. Epub 2009 Jan 14.
Abstract/Text
BACKGROUND: Blood flow in the corpus luteum (CL) is associated with luteal function. The present study was undertaken to investigate whether luteal function can be improved by increasing CL blood flow in women with luteal phase defect (LFD). METHODS: Blood flow impedance in the CL was measured by transvaginal color-pulsed-Doppler-ultrasonography and was expressed as a resistance index (RI). The patients with both LFD [serum progesterone (P) concentrations < 10 ng/ml during mid-luteal phase] and high CL-RI (>/= 0.51) were given vitamin-E (600 mg/day, n = 18), L-arginine (6 g/day, n = 14) as a potential nitric oxide donor, melatonin (3 mg/day, n = 13) as an antioxidant, or HCG (2,000 IU/day, n = 10) during the subsequent menstrual cycle. RESULTS: In the control group (n = 11), who received no medication to increase CL blood flow, only one patient (9%) improved in CL-RI and 2 patients (18%) improved in serum P. Vitamin-E improved CL-RI in 15 patients (83%) and improved serum P in 12 patients (67%). L-arginine improved CL-RI in all the patients (100%) and improved serum P in 10 patients (71%). HCG improved CL-RI in all the patients (100%) and improved serum P in 9 patients (90%). Melatonin had no significant effect. CONCLUSION: Vitamin-E or L-arginine treatment improved luteal function by decreasing CL blood flow impedance. CL blood flow is a critical factor for luteal function.
PMID 19144154 J Ovarian Res. 2009 Jan 14;2:1. doi: 10.1186/1757-2215-2-1. Epub 2009 Jan 14.
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