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著者: Ichiro Miwa, Hiroshi Tamura, Akihisa Takasaki, Yoshiaki Yamagata, Katsunori Shimamura, Norihiro Sugino
雑誌名: Fertil Steril. 2009 Apr;91(4):998-1004. doi: 10.1016/j.fertnstert.2008.01.029. Epub 2008 Mar 6.
Abstract/Text
OBJECTIVE: To characterize pathophysiologic features of a "thin" endometrium. DESIGN: A prospective observational study. SETTING: University Hospital and City General Hospital. PATIENT(S): Patients with normal-thickness endometrium (Normal-Em group: endometrial thickness >or=8 mm; n = 57) and thin endometrium (Thin-Em group: endometrial thickness <8 mm; n = 17). MAIN OUTCOME MEASURE(S): Blood flow impedance of the uterine radial artery (RA) was assessed as resistance index (RI) by transvaginal color-pulsed Doppler ultrasonography. The area of glandular epithelium, the number of blood vessels, and vascular endothelial growth factor (VEGF) expression were examined in the midluteal-phase endometrium. RESULT(S): The RA-RI in the Thin-Em group was significantly higher than in the Normal-Em group throughout the menstrual cycle. Endometrial thickness was significantly correlated with RA-RI. Growth of glandular epithelium, the number of blood vessels, and VEGF expression were significantly lower in the Thin-Em group than in the Normal-Em group. CONCLUSION(S): A "thin" endometrium was characterized by high blood flow impedance of RA, poor epithelial growth, decreased VEGF expression, and poor vascular development.
PMID 18328483 Fertil Steril. 2009 Apr;91(4):998-1004. doi: 10.1016/j.fertnstert.2008.01.029. Epub 2008 Mar 6.
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