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著者: Takashi Takeda, Akiko Kondo, Shoko Koga, Jun Hayakawa, Kenichi Hayakawa, Keizo Hiramatsu, Nobuo Yaegashi
雑誌名: J Obstet Gynaecol Res. 2015 Oct;41(10):1584-90. doi: 10.1111/jog.12774. Epub 2015 Aug 26.
Abstract/Text
AIM: A combined oral contraceptive containing ethinylestradiol 20 µg plus drospirenone 3 mg (EE20 + DRSP) in a 24/4 regimen has been shown to alleviate the symptoms of premenstrual syndrome and premenstrual dysphoric disorder. This study was conducted to evaluate the efficacy of EE20 + DRSP in Japanese patients with premenstrual symptoms.
MATERIAL AND METHODS: A multicenter, prospective, open-label, single-arm, phase IV study was performed in Japanese women with dysmenorrhea and premenstrual symptoms. They were treated with EE20 + DRSP to alleviate the symptoms of dysmenorrhea for six treatment cycles. Premenstrual symptoms were evaluated using a Premenstrual Symptoms Questionnaire at baseline and after three and six cycles of EE20 + DRSP. The degree of dysmenorrhea was also evaluated using a visual analog scale at baseline and after one, three, and six cycles of EE20 + DRSP.
RESULTS: Forty-eight patients were treated with EE20 + DRSP. Most of the premenstrual symptoms were alleviated significantly by three and six cycles of EE20 + DRSP treatment. EE20 + DRSP treatment significantly improved the severity of premenstrual symptoms. We also confirmed the effectiveness of EE20 + DRSP for the treatment for dysmenorrhea.
CONCLUSION: This study showed that EE20 + DRSP could be a useful treatment strategy for premenstrual symptoms in Japanese women.
© 2015 Japan Society of Obstetrics and Gynecology.
PMID 26310836 J Obstet Gynaecol Res. 2015 Oct;41(10):1584-90. doi: 10.1111/jog.12774. Epub 2015 Aug 26.
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