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著者: A S Cruise, A Singh, R E Quiney
雑誌名: J Laryngol Otol. 2010 Jun;124(6):583-6. doi: 10.1017/S0022215110000241. Epub 2010 Feb 18.
Abstract/Text
OBJECTIVES: To review the current literature on the use of sodium fluoride in the treatment of otosclerosis.
DESIGN: A literature review was conducted, searching the Medline and PubMed database from 1966 to 2009, using the terms 'otosclerosis' and 'fluoride'. Article abstracts were reviewed and relevant full articles acquired.
RESULTS: There has been only one double-blind, placebo-controlled trial of the use of sodium fluoride in otosclerosis patients, and this found a reduced incidence of deterioration in hearing after two years in the treatment group. Several case-control series have described a hearing benefit in the sodium fluoride treated group. Treatment doses vary greatly, and there is no evidence regarding the optimum duration of treatment.
CONCLUSIONS: There is low quality evidence suggesting that sodium fluoride may be of benefit to preserve hearing and reduce vestibular symptoms in patients with otosclerosis.
PMID 20163750 J Laryngol Otol. 2010 Jun;124(6):583-6. doi: 10.1017/S0022215110000241. Epub 2010 Feb 18.
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