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著者: Andrea Ciorba, Roberto Bovo, Patrizia Trevisi, Chiara Bianchini, Rosa Arboretti, Alessandro Martini
雑誌名: Eur Arch Otorhinolaryngol. 2009 Oct;266(10):1539-46. doi: 10.1007/s00405-009-0944-5. Epub 2009 Mar 13.
Abstract/Text
The aim of the study was to characterize the audiological consequences of congenital cytomegalovirus infection (CMV) and to evaluate the outcome of rehabilitation with hearing aids and/or cochlear implant (CI), associated with an adequate speech-language therapy. A retrospective review of data was made from a total of 16 infants, affected by severe to profound hearing loss from congenital CMV infection, referred to a tertiary audiological center for rehabilitation. Audiological evaluation was performed using behavioral audiometry, auditory brainstem responses (ABR) and/or electrocochleography (ECochG). Of the 16 children (median age at diagnosis of hearing loss: 21.33 +/- 0.7 months) with CMV hearing loss, 14 were affected by profound bilateral hearing loss and received a CI, while 2 were affected by bilateral severe hearing loss and received hearing aids. Cochlear implants can provide useful speech comprehension to patients with CMV-related deafness, even if language development is lower when compared to a group of Connexin (Cx) 26+ cochlear-implanted children (eight subjects), matched for age. Congenital CMV infection still represents a serious clinical condition, as well as an important cause of hearing loss in children. More studies have claimed to identify the pathophysiological mechanisms of damage and thus to ensure a better therapeutic approach. Nonetheless, in cases of CMV-deafened babies, the overall outcome of cochlear implantation is good.
PMID 19283400 Eur Arch Otorhinolaryngol. 2009 Oct;266(10):1539-46. doi: 10.1007/s00405-009-0944-5. Epub 2009 Mar 13.
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