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著者: S Murakami, M Mizobuchi, Y Nakashiro, T Doi, N Hato, N Yanagihara
雑誌名: Ann Intern Med. 1996 Jan 1;124(1 Pt 1):27-30.
Abstract/Text
OBJECTIVE: To determine whether herpes simplex virus type 1 (HSV-1) causes Bell palsy.
DESIGN: Prospective study.
SETTING: University inpatient service.
PATIENTS: 14 patients with Bell palsy, 9 patients with the Ramsay-Hunt syndrome, and 12 other controls.
MEASUREMENTS: Viral genomes of HSV-1, varicella-zoster virus, and Epstein-Barr virus were analyzed in clinical samples of facial nerve endoneurial fluid and posterior auricular muscle using polymerase chain reaction (PCR) followed by hybridization with Southern blot analysis.
RESULTS: Herpes simplex virus type 1 genomes were detected in 11 of 14 patients (79%) with Bell palsy but not in patients with the Ramsay-Hunt syndrome or in other controls. The nucleotide sequences of the PCR fragments were identical to those of the HSV-1 genome.
CONCLUSIONS: Herpes simplex virus type 1 is the major etiologic agent in Bell palsy.
PMID 7503474 Ann Intern Med. 1996 Jan 1;124(1 Pt 1):27-30.
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