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著者: Hao Wen, Lucine Vuitton, Tuerhongjiang Tuxun, Jun Li, Dominique A Vuitton, Wenbao Zhang, Donald P McManus
雑誌名: Clin Microbiol Rev. 2019 Mar 20;32(2). doi: 10.1128/CMR.00075-18. Epub 2019 Feb 13.
Abstract/Text
Echinococcosis is a zoonosis caused by cestodes of the genus Echinococcus (family Taeniidae). This serious and near-cosmopolitan disease continues to be a significant public health issue, with western China being the area of highest endemicity for both the cystic (CE) and alveolar (AE) forms of echinococcosis. Considerable advances have been made in the 21st century on the genetics, genomics, and molecular epidemiology of the causative parasites, on diagnostic tools, and on treatment techniques and control strategies, including the development and deployment of vaccines. In terms of surgery, new procedures have superseded traditional techniques, and total cystectomy in CE, ex vivo resection with autotransplantation in AE, and percutaneous and perendoscopic procedures in both diseases have improved treatment efficacy and the quality of life of patients. In this review, we summarize recent progress on the biology, epidemiology, diagnosis, management, control, and prevention of CE and AE. Currently there is no alternative drug to albendazole to treat echinococcosis, and new compounds are required urgently. Recently acquired genomic and proteomic information can provide a platform for improving diagnosis and for finding new drug and vaccine targets, with direct impact in the future on the control of echinococcosis, which continues to be a global challenge.
Copyright © 2019 American Society for Microbiology.
PMID 30760475 Clin Microbiol Rev. 2019 Mar 20;32(2). doi: 10.1128/CMR.00075-18. Epub 2019 Feb 13.
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