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著者: Luc G T Morris, Saral Mehra, Jatin P Shah, Mark H Bilsky, Samuel H Selesnick, Dennis H Kraus
雑誌名: Head Neck. 2012 Sep;34(9):1231-9. doi: 10.1002/hed.21883. Epub 2011 Sep 23.
Abstract/Text
BACKGROUND: The purpose of this study was to identify factors predictive of outcome in patients undergoing temporal bone resection (TBR) for head and neck cancer.
METHODS: This was a retrospective study of 72 patients undergoing TBR. Factors associated with survival and recurrence were identified on multivariable regression.
RESULTS: Most tumors were epithelial (81%), commonly (69%) involving critical structures. Cervical metastases were uncommon (6%). Squamous cell carcinoma (SCC) of the external auditory canal carried a high rate of parotid invasion (25%) and parotid nodal metastases (43%). The 5-year rate of overall survival (OS) was 62%; disease-specific survival (DSS), 70%; recurrence-free survival (RFS), 46%. Factors independently associated with outcome on multivariable analysis were margin status and extratemporal spread of disease to the parotid, mandible, or regional nodes. Recurrence was common (72%) in cT3-4 tumors.
CONCLUSIONS: Margin status and extratemporal disease spread are the strongest independent predictors of survival and recurrence. In SCC of the external auditory canal, high rates of parotid involvement support adjunctive parotidectomy. Risk of recurrence in T3-T4 tumors may support a role for adjuvant therapy.
Copyright © 2011 Wiley Periodicals, Inc.
PMID 21953902 Head Neck. 2012 Sep;34(9):1231-9. doi: 10.1002/hed.21883. Epub 2011 Sep 23.
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