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著者: Keisuke Matsusaki, Kazumasa Orihashi
雑誌名: Artif Organs. 2020 Oct;44(10):1090-1097. doi: 10.1111/aor.13691. Epub 2020 Apr 20.
Abstract/Text
Efficacy for alleviating signs/symptoms of malignant ascites of a renovated CART (cell-free and concentrated ascites reinfusion therapy) system, called KM-CART, was evaluated. A total of 4781 KM-CART procedures were performed in 2109 patients. All patients were accepted unless hemodynamically unstable or consciousness impaired. The ascites were processed and drip-infused into the patient. There were no major complications or deaths. The mean drainage volume was 6.2 L (maximum: 27.7 L), patient symptoms (numerical scale system) were significantly alleviated (45.1 ± 19.0 reduced to 21.2 ± 14.2, P < .001), and patient leg circumference significantly decreased (33.3 ± 4.4 cm reduced to 30.5 ± 4.4 cm, P < .001) without exacerbation of renal function. Collected cancer cells could be utilized for immune therapy. KM-CART is capable of improving the "quality of best supportive care" and can be beneficial in conjunction with medication for alleviating malignant pain.
© 2020 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.
PMID 32242939 Artif Organs. 2020 Oct;44(10):1090-1097. doi: 10.1111/aor.13691. Epub 2020 Apr 20.
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