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著者: Alpha Kabinet Keita, Fara R Koundouno, Martin Faye, Ariane Düx, Julia Hinzmann, Haby Diallo, Ahidjo Ayouba, Frederic Le Marcis, Barré Soropogui, Kékoura Ifono, Moussa M Diagne, Mamadou S Sow, Joseph A Bore, Sebastien Calvignac-Spencer, Nicole Vidal, Jacob Camara, Mamadou B Keita, Annick Renevey, Amadou Diallo, Abdoul K Soumah, Saa L Millimono, Almudena Mari-Saez, Mamadou Diop, Ahmadou Doré, Fodé Y Soumah, Kaka Kourouma, Nathalie J Vielle, Cheikh Loucoubar, Ibrahima Camara, Karifa Kourouma, Giuditta Annibaldis, Assaïtou Bah, Anke Thielebein, Meike Pahlmann, Steven T Pullan, Miles W Carroll, Joshua Quick, Pierre Formenty, Anais Legand, Karla Pietro, Michael R Wiley, Noel Tordo, Christophe Peyrefitte, John T McCrone, Andrew Rambaut, Youssouf Sidibé, Mamadou D Barry, Madeleine Kourouma, Cé D Saouromou, Mamadou Condé, Moussa Baldé, Moriba Povogui, Sakoba Keita, Mandiou Diakite, Mamadou S Bah, Amadou Sidibe, Dembo Diakite, Fodé B Sako, Fodé A Traore, Georges A Ki-Zerbo, Philippe Lemey, Stephan Günther, Liana E Kafetzopoulou, Amadou A Sall, Eric Delaporte, Sophie Duraffour, Ousmane Faye, Fabian H Leendertz, Martine Peeters, Abdoulaye Toure, N' Faly Magassouba
雑誌名: Nature. 2021 Sep;597(7877):539-543. doi: 10.1038/s41586-021-03901-9. Epub 2021 Sep 15.
Abstract/Text
Seven years after the declaration of the first epidemic of Ebola virus disease in Guinea, the country faced a new outbreak-between 14 February and 19 June 2021-near the epicentre of the previous epidemic1,2. Here we use next-generation sequencing to generate complete or near-complete genomes of Zaire ebolavirus from samples obtained from 12 different patients. These genomes form a well-supported phylogenetic cluster with genomes from the previous outbreak, which indicates that the new outbreak was not the result of a new spillover event from an animal reservoir. The 2021 lineage shows considerably lower divergence than would be expected during sustained human-to-human transmission, which suggests a persistent infection with reduced replication or a period of latency. The resurgence of Zaire ebolavirus from humans five years after the end of the previous outbreak of Ebola virus disease reinforces the need for long-term medical and social care for patients who survive the disease, to reduce the risk of re-emergence and to prevent further stigmatization.
© 2021. The Author(s), under exclusive licence to Springer Nature Limited.
PMID 34526718 Nature. 2021 Sep;597(7877):539-543. doi: 10.1038/s41586-021-03901-9. Epub 2021 Sep 15.
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