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著者: Masatoshi Minamisawa, Jun Koyama, Yoshiki Sekijima, Shu-ichi Ikeda, Ayako Kozuka, Soichiro Ebisawa, Takashi Miura, Hirohiko Motoki, Ayako Okada, Atsushi Izawa, Uichi Ikeda
雑誌名: Eur Heart J Cardiovasc Imaging. 2016 Apr;17(4):402-10. doi: 10.1093/ehjci/jew003. Epub 2016 Feb 11.
Abstract/Text
AIMS: To compare cardiac function in patients with the two types of transthyretin (TTR)-related amyloidoses [wild-type (wt) and mutated (m) TTR amyloidoses (ATTR)] using standard and speckle tracking echocardiography (STE).
METHODS AND RESULTS: Twenty-one consecutive patients with biopsy-proved ATTRwt were compared with 21 patients with ATTRm from the database, matched by age and left ventricular (LV) wall thickness (n = 135, ATTRm). All patients were examined using 2D echocardiography. Apical four- and two-chamber, and long-axis views and basal, mid, and apical short-axis views were used to examine LV longitudinal, circumferential, and radial strains. LV ejection fraction (EF), LV basal circumferential/radial strain, and mid-radial strain were significantly lower in patients with ATTRwt compared with patients with ATTRm. There was no significant difference between the two groups in the other parameters. In the receiver-operating characteristic curve analysis, LVEF and LV basal mean radial strain were the best parameters for distinguishing between the two groups.
CONCLUSION: Patients with ATTRwt are characterized by lower LVEF, LV basal, and LV mid-radial strains compared with patients with ATTRm. LVEF and LV radial strain are useful in distinguishing between ATTRwt and ATTRm when TTR has been proved in biopsy specimens.
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions please email: journals.permissions@oup.com.
PMID 26873458 Eur Heart J Cardiovasc Imaging. 2016 Apr;17(4):402-10. doi: 10.1093/ehjci/jew003. Epub 2016 Feb 11.
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