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著者: Cory Anderson, Timothy Lynch, Ronish Gupta, Rodrick K Lim
雑誌名: J Emerg Med. 2018 Dec;55(6):e141-e145. doi: 10.1016/j.jemermed.2018.09.015. Epub 2018 Oct 2.
Abstract/Text
BACKGROUND: Pediatric exposure to prazosin is unusual because it is most commonly indicated for the treatment of hypertension. Prazosin's increase in popularity as a treatment for posttraumatic stress disorder makes it important for emergency physicians to be aware of how to manage potential toxic ingestion because of prazosin overdose. CASE REPORT: A 16-year-old, 76-kg female presented after ingesting 110 mg of prazosin, 209.3 g of acetaminophen, and 55 g of naproxen. She was admitted to the pediatric intensive care unit for rapidly deteriorating hypotension (lowest blood pressure 47/19 mm Hg) refractory to aggressive fluid resuscitation and infusions of epinephrine and norepinephrine each at 0.5 mcg/kg/min. Stabilization of blood pressure was eventually achieved, and associated with use of a vasopressin infusion of 0.004 units/kg/min. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Because of the increasing exposure of children to prazosin, clinicians should be aware of the pharmacology behind alpha-1 antagonist overdose and consider treatment options, such as vasopressin, when hypotension is resistant to standard fluid and catecholamine therapy.
Copyright © 2018 Elsevier Inc. All rights reserved.
PMID 30287134 J Emerg Med. 2018 Dec;55(6):e141-e145. doi: 10.1016/j.jemermed.2018.09.015. Epub 2018 Oct 2.
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