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img  3:  Anti-anaerobic coverage is not necessary for Klebsiella pneumoniae liver abscess: a propensity score-matched cohort study.
 
著者: Hyun Ah Kim, Doo Ryeon Chung, Joon-Sup Yeom, Hyun Kyun Ki, Hae Suk Cheong, Jun Seong Son, Jin Seo Lee, Soo-Youn Moon, Seung Soon Lee, Jeong-A Lee, Kyung-Hwa Park, Seung-Ji Kang, Sook-In Jung, Shin-Woo Kim, Hyun Ha Chang, Seong Yeol Ryu, Ki Tae Kwon, Chisook Moon, Yu Mi Wi, Sang Taek Heo, Mi Kyong Joung, Cheol-In Kang, Kyong Ran Peck, Jae-Hoon Song
雑誌名: Diagn Microbiol Infect Dis. 2015 Jan;81(1):60-5. doi: 10.1016/j.diagmicrobio.2014.10.002. Epub 2014 Oct 13.
Abstract/Text Although most Klebsiella pneumoniae liver abscesses have been reported to be monomicrobial, clinical outcomes have not been compared between antimicrobial therapy with and without anti-anaerobic coverage. A propensity score-matched cohort study was conducted using the 731 cases of K. pneumoniae liver abscess. Clinical outcomes were compared between a group discontinuing anti-anaerobic agents after K. pneumoniae identification and a group continuing. A total of 170 cases were matched at a 1:1 ratio using their propensity to discontinue anti-anaerobic agents. The McNemar's test showed no difference in mortality rates (1.8% for discontinuation versus 2.3% for continuation; P = 1.00) or relapse (1.8% versus 2.9%; P = 0.73) between groups. Early discontinuation of anti-anaerobic agents had no association with treatment failure by means of the generalized estimating equation model (odds ratio 0.48; P = 0.14) and the Kaplan-Meier method (P = 0.85) in matched groups. Early discontinuation of anti-anaerobic agents does not affect the clinical outcomes of patients with K. pneumoniae liver abscess.

Copyright © 2015 Elsevier Inc. All rights reserved.
PMID 25459498  Diagn Microbiol Infect Dis. 2015 Jan;81(1):60-5. doi: 10.1016/j.diagmicrobio.2014.10.002. Epub 2014 Oct 13.
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