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著者: Guan-qun Chao, Shuo Zhang
雑誌名: Intern Med. 2013;52(4):419-24. Epub 2013 Feb 15.
Abstract/Text
OBJECTIVE: We aimed to evaluate the efficacy of amitriptyline as a therapeutic option for irritable bowel syndrome (IBS) through a meta-analysis of randomized controlled trials.
METHODS: For the years from 1966 until May 2012, PubMed, Scopus, Web of Science and the Cochrane Central Register of Controlled Trials were searched for double-blind, placebo-controlled trials investigating the efficacy of amitriptyline in the management of IBS.
RESULTS: Four randomized, placebo-controlled clinical trials met our criteria and were included in the meta-analysis. The pooled relative risk for clinical improvement with amitriptyline therapy was 4.18 (95% CI: 2.00 to 8.77, p=0.0001).
CONCLUSION: It was thus concluded that amitriptyline exhibits a clinically and statistically significant control of IBS symptoms.
PMID 23411695 Intern Med. 2013;52(4):419-24. Epub 2013 Feb 15.
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