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著者: Seiji Ishiguro, Shizuka Sasazuki, Manami Inoue, Norie Kurahashi, Motoki Iwasaki, Shoichiro Tsugane, JPHC Study Group
雑誌名: Cancer Lett. 2009 Mar 18;275(2):240-6. doi: 10.1016/j.canlet.2008.10.020. Epub 2008 Nov 25.
Abstract/Text
We examined the effect of alcohol consumption, cigarette smoking and flushing response on esophageal squamous cell carcinoma (ESCC) in a large-scale population-based cohort study. 44,970 middle-aged and older Japanese men were followed. A total of 215 cases of ESCC were newly diagnosed. Alcohol consumption and cigarette smoking are strongly associated with the incidence of ESCC. Heavy alcohol consumption increased the risk of ESCC especially among heavy smokers with the flushing response (HR = 3.41, 95% CI = 2.10-5.51). Strong effect modification was detected in heavy smokers. Our results suggest that heavy alcohol consumption together with heavy smoking may increase the risk of ESCC particularly in individuals with the flushing response.
PMID 19036500 Cancer Lett. 2009 Mar 18;275(2):240-6. doi: 10.1016/j.canlet.2008.10.020. Epub 2008 Nov 25.
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