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著者: Kohji Shirai, Atsuhito Saiki, Shinichi Oikawa, Tamio Teramoto, Nobuhiro Yamada, Shun Ishibashi, Norio Tada, Shigeru Miyazaki, Ikuo Inoue, Shunichi Murano, Naoki Sakane, Noriko Satoh-Asahara, Hideaki Bujo, Yoh Miyashita, Yasushi Saito
雑誌名: Obes Res Clin Pract. 2013 Jan-Feb;7(1):e43-54. doi: 10.1016/j.orcp.2012.03.002.
Abstract/Text
AIMS: To clarify the usefulness of protein-sparing modified formula diet in obese type 2 diabetic patients, the effects of partial use of formula diet on weight reduction and changes in related metabolic variables, and the improving rates of risk factors per 1% body weight reduction, were compared with those of conventional subcaloric diet.
SUBJECTS AND METHODS: Obese patients [BMI >25 kg/m²] with diabetic mellitus were randomly assigned to a low-caloric diet with partial use of formula diet group (FD, n = 119) and a conventional low-caloric diet group (CD, n = 110). Subjects in FD took one pack of formula diet (MicroDiet®, 240 kcal/pack) in place of one of three daily low-caloric meals for 24 weeks. Total daily calorie prescribed was same.
RESULT: Weight reduction was greater in FD than in CD (week 24: -3.5 vs -1.4 kg; all p < 0.001). Systolic blood pressure decreased significantly only in FD. HbA1c reduction was greater in FD than in CD. HDL-cholesterol increased significantly more in FD than in CD (week 24: +2.8 vs. +0.6 mg/dl, p < 0.001). Among several improving rates (%) of risk factors/1% body weight reduction, those of HbA1c at weeks 16 and 24, triglyceride at week 8 and HDL-cholesterol at week 24, were significantly higher in FD than CD. Doses of sulfonylurea and thiazolidinedione were significantly decreased in FD than in CD.
CONCLUSION: Partial use of formula diet was much more effective in reducing body weight, and also in improving coronary risk factors than conventional diet in part due to reduced body weight through decreased energy diet intake and due to dietary composition of the formula diet.
© 2013 Asian Oceanian Association for the Study of Obesity . Published by Elsevier Ltd. All rights reserved.
PMID 24331681 Obes Res Clin Pract. 2013 Jan-Feb;7(1):e43-54. doi: 10.1016/j.orcp.2012.03.002.
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