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著者: David J A Jenkins, J David Spence, Edward L Giovannucci, Young-In Kim, Robert Josse, Reinhold Vieth, Sonia Blanco Mejia, Effie Viguiliouk, Stephanie Nishi, Sandhya Sahye-Pudaruth, Melanie Paquette, Darshna Patel, Sandy Mitchell, Meaghan Kavanagh, Tom Tsirakis, Lina Bachiri, Atherai Maran, Narmada Umatheva, Taylor McKay, Gelaine Trinidad, Daniel Bernstein, Awad Chowdhury, Julieta Correa-Betanzo, Gabriella Del Principe, Anisa Hajizadeh, Rohit Jayaraman, Amy Jenkins, Wendy Jenkins, Ruben Kalaichandran, Geithayini Kirupaharan, Preveena Manisekaran, Tina Qutta, Ramsha Shahid, Alexis Silver, Cleo Villegas, Jessica White, Cyril W C Kendall, Sathish C Pichika, John L Sievenpiper
雑誌名: J Am Coll Cardiol. 2018 Jun 5;71(22):2570-2584. doi: 10.1016/j.jacc.2018.04.020.
Abstract/Text
The authors identified individual randomized controlled trials from previous meta-analyses and additional searches, and then performed meta-analyses on cardiovascular disease outcomes and all-cause mortality. The authors assessed publications from 2012, both before and including the U.S. Preventive Service Task Force review. Their systematic reviews and meta-analyses showed generally moderate- or low-quality evidence for preventive benefits (folic acid for total cardiovascular disease, folic acid and B-vitamins for stroke), no effect (multivitamins, vitamins C, D, β-carotene, calcium, and selenium), or increased risk (antioxidant mixtures and niacin [with a statin] for all-cause mortality). Conclusive evidence for the benefit of any supplement across all dietary backgrounds (including deficiency and sufficiency) was not demonstrated; therefore, any benefits seen must be balanced against possible risks.
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
PMID 29852980 J Am Coll Cardiol. 2018 Jun 5;71(22):2570-2584. doi: 10.1016/j.jacc.2018.04.020.
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