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著者: Stephanie Farah, Kaissar Yammine
雑誌名: Nutr Rev. 2022 Apr 8;80(5):1340-1355. doi: 10.1093/nutrit/nuab116.
Abstract/Text
CONTEXT: Diabetic peripheral neuropathy (DPN) is a common complication.
OBJECTIVE: To re-evaluate the role of vitamin B supplementation on reducing the signs and symptoms of DPN.
DATA SOURCES: Electronic databases such as PubMed, Cochrane Library, and Medline.
DATA EXTRACTION: An Excel spreadsheet was used to report the extracted relevant data.
DATA ANALYSIS: Fourteen randomized controlled trials were selected, comprising a pooled sample of 997 study subjects. The pooled odds ratio values were 3.1 (95%CI, 1.197-8.089) and 3.04 (95%CI, 1.556-5.937) for pain and dysesthesia outcomes, respectively. For the amplitude change in electromyography of the sensory sural nerve, the weighted difference from 2 studies was 0.37 (95%CI, 0.034-0.709) in favor of intervention. Peak latency changes were in favor of the intervention group. Two studies yielded a weighted difference of 0.571 (95%CI, 0.310-0.831) for the velocity outcome in favor of intervention. Unlike the fibular nerve, the electromyographic motor outcomes of the tibial nerve were in favor of vitamin B supplementation.
CONCLUSION: Vitamin B supplementation could improve many symptoms and signs of DPN.
© The Author(s) 2022. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PMID 34990506 Nutr Rev. 2022 Apr 8;80(5):1340-1355. doi: 10.1093/nutrit/nuab116.
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