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著者: F Auquer, F Cordón, E Gorina, J C Caballero, C Adalid, J Batlle, Urinary Tract Infection Study Group
雑誌名: Clin Microbiol Infect. 2002 Jan;8(1):50-4.
Abstract/Text
A double-blind, randomized controlled study to evaluate the efficacy and safety of a single dose of 500 mg of ciprofloxacin versus 3 days 400 mg twice-daily of norfloxacin in uncomplicated urinary tract infection in women was designed. Patients underwent four visits: baseline, and at 3, 7 and 28 days. The main efficacy variables were clinical and microbiological outcome at day 7. Analyses on both valid patients and intention-to-treat populations were performed. Two hundred and twenty-six patients (114 receiving ciprofloxacin and 112 receiving norfloxacin) were considered valid for efficacy evaluation. Bacteriologic cure was 91.2% in the ciprofloxacin group and 91.9% in the norfloxacin group. Clinical resolution was 91.2 and 93.8%, respectively. Both treatments were equally efficacious (P = 0.016).
PMID 11906502 Clin Microbiol Infect. 2002 Jan;8(1):50-4.
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