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著者: M Piepoli, G Q Villani, P Ponikowski, A Wright, M D Flather, A J Coats
雑誌名: Int J Cardiol. 1998 Sep 1;66(1):1-10.
Abstract/Text
Unlike other antiarrhythmic class I drugs, amiodarone showed in preliminary studies, benefits also in patients with left ventricular dysfunction. These positive results have induced the development of large randomised controlled studies: their results are reviewed and the controversial points are discussed. In a meta-analysis of randomised controlled trials the use of amiodarone in heart failure was associated with an approximate 20 to 25% reduction in deaths. However, amiodarone was also associated with a 120 to 124% increase in side effects.
PMID 9781781 Int J Cardiol. 1998 Sep 1;66(1):1-10.
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