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著者: Jelena R Ghadri, Annahita Sarcon, Johanna Diekmann, Dana Roxana Bataiosu, Victoria L Cammann, Stjepan Jurisic, Lars Christian Napp, Milosz Jaguszewski, Frank Scherff, Peter Brugger, Lutz Jäncke, Burkhardt Seifert, Jeroen J Bax, Frank Ruschitzka, Thomas F Lüscher, Christian Templin, InterTAK Co-investigators:
雑誌名: Eur Heart J. 2016 Oct 1;37(37):2823-2829. doi: 10.1093/eurheartj/ehv757. Epub 2016 Mar 2.
Abstract/Text
AIMS: Takotsubo syndrome (TTS) is typically provoked by negative stressors such as grief, anger, or fear leading to the popular term 'broken heart syndrome'. However, the role of positive emotions triggering TTS remains unclear. The aim of the present study was to analyse the prevalence and characteristics of patients with TTS following pleasant events, which are distinct from the stressful or undesirable episodes commonly triggering TTS.
METHODS AND RESULTS: Takotsubo syndrome patients with preceding pleasant events were compared to those with negative emotional triggers from the International Takotsubo Registry. Of 1750 TTS patients, we identified a total of 485 with a definite emotional trigger. Of these, 4.1% (n = 20) presented with pleasant preceding events and 95.9% (n = 465) with unequivocal negative emotional events associated with TTS. Interestingly, clinical presentation of patients with 'happy heart syndrome' was similar to those with the 'broken heart syndrome' including symptoms such as chest pain [89.5% (17/19) vs. 90.2% (412/457), P = 1.0]. Similarly, electrocardiographic parameters, laboratory findings, and 1-year outcome did not differ. However, in a post hoc analysis, a disproportionate higher prevalence of midventricular involvement was noted in 'happy hearts' compared with 'broken hearts' (35.0 vs. 16.3%, P = 0.030).
CONCLUSION: Our data illustrate that TTS can be triggered by not only negative but also positive life events. While patient characteristics were similar between groups, the midventricular TTS type was more prevalent among the 'happy hearts' than among the 'broken hearts'. Presumably, despite their distinct nature, happy and sad life events may share similar final common emotional pathways, which can ultimately trigger TTS.
© The Author 2016. Published by Oxford University Press on behalf of the European Society of Cardiology.
PMID 26935270 Eur Heart J. 2016 Oct 1;37(37):2823-2829. doi: 10.1093/eurheartj/ehv757. Epub 2016 Mar 2.
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