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著者: Kazumi Kawase, Dominick J Dimaio, Susan L Tucker, Thomas A Buchholz, Merrick I Ross, Barry W Feig, Henry M Kuerer, Funda Meric-Bernstam, Gildy Babiera, Frederick C Ames, S Eva Singletary, Kelly K Hunt
雑誌名: Ann Surg Oncol. 2005 May;12(5):391-7. doi: 10.1245/ASO.2005.05.026. Epub 2005 Mar 29.
Abstract/Text
BACKGROUND: The optimal surgical management of Paget's disease of the breast remains to be defined. Mastectomy has been the standard of care, but several institutions have recently advocated breast-conserving surgery, particularly for patients with minimal disease. In an effort to develop rational treatment guidelines, we examined our institutional experience with Paget's disease of the breast.
METHODS: Patients with Paget's disease of the breast who had surgical therapy at our institution between 1949 and 1993 were reviewed. In addition to patient and tumor characteristics, charts were reviewed for treatment modalities, locoregional recurrence patterns, and survival. Subgroups were compared for differences in survival in both univariate and multivariate analyses.
RESULTS: A total of 104 patients met the study criteria. The most common presenting symptoms were nipple discharge and eczematous changes of the nipple/areola complex. Ninety-seven patients (93.2%) had an underlying invasive or noninvasive cancer associated with Paget's disease. Ninety-two patients (88.5%) underwent mastectomy, and 12 (11.5%) had a breast-conserving procedure. On univariate analysis, patients with age <60 years at diagnosis, stage II disease, positive lymph nodes, invasive disease, or a palpable mass had significantly lower 10-year disease-specific and recurrence-free survival. There were four locoregional recurrences (three after mastectomy and one after breast conservation). There were no significant differences in overall, disease-specific, or recurrence-free survival according to the type of surgery.
CONCLUSIONS: Paget's disease of the breast is almost always associated with an underlying breast cancer. Breast-conserving approaches result in local control and survival rates similar to those achieved with mastectomy.
PMID 15915373 Ann Surg Oncol. 2005 May;12(5):391-7. doi: 10.1245/ASO.2005.05.026. Epub 2005 Mar 29.
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