| |
著者: Keiichiro Tada, Akiko Ogiya, Kiyomi Kimura, Hidetomo Morizono, Kotaro Iijima, Yumi Miyagi, Seiichiro Nishimura, Masujiro Makita, Rie Horii, Futoshi Akiyama, Takuji Iwase
雑誌名: World J Surg Oncol. 2010 Jan 27;8:6. doi: 10.1186/1477-7819-8-6. Epub 2010 Jan 27.
Abstract/Text
BACKGROUND: The impact of sentinel lymph node biopsy on breast cancer mimicking ductal carcinoma in situ (DCIS) is a matter of debate.
METHODS: We studied the rate of occurrence of sentinel lymph node metastasis in 255 breast cancer patients with pure DCIS showing no invasive components on routine pathological examination. We compared this to the rate of occurrence in 177 patients with predominant intraductal-component (IDC) breast cancers containing invasive foci equal to or less than 0.5 cm in size.
RESULTS: Most of the clinical and pathological baseline characteristics were the same between the two groups. However, peritumoral lymphatic permeation occurred less often in the pure DCIS group than in the IDC-predominant invasive-lesion group (1.2% vs. 6.8%, p = 0.002). One patient (0.39%) with pure DCIS had two sentinel lymph nodes positive for metastasis. This rate was significantly lower than that in patients with IDC-predominant invasive lesions (6.2%; p < 0.001).
CONCLUSIONS: Because the rate of sentinel lymph node metastasis in pure DCIS is very low, sentinel lymph node biopsy can safely be omitted.
PMID 20105298 World J Surg Oncol. 2010 Jan 27;8:6. doi: 10.1186/1477-7819-8-6. Epub 2010 Jan 27.
|
