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著者: A Diehl, I Reinhard, A Schmitt, K Mann, W F Gattaz
雑誌名: Eur Psychiatry. 2009 Jan;24(1):33-40. doi: 10.1016/j.eurpsy.2008.07.007. Epub 2008 Sep 6.
Abstract/Text
BACKGROUND: Tardive dyskinesia (TD) is a movement disorder observed after chronic neuroleptic treatment. Smoking is presumed to increase the prevalence of TD. The question of a cause-effect-relationship between smoking and TD, however, remains to be answered. Purpose of this study was to examine the correlation between the degree of smoking and the severity of TD with respect to differences caused by medication.
METHOD: We examined 60 patients suffering from schizophrenia and TD. We compared a clozapine-treated group with a group treated with typical neuroleptics. Movement disorders were assessed using the Abnormal-Involuntary-Movement-Scale and the technical device digital image processing, providing rater independent information on perioral movements.
RESULTS: We found a strong correlation (.80CONCLUSION: Concerning a possible cause-effect-relationship between smoking and TD, smoking is more of a general health hazard than neuroleptic exposure in terms of TD.
PMID 18774276 Eur Psychiatry. 2009 Jan;24(1):33-40. doi: 10.1016/j.eurpsy.2008.07.007. Epub 2008 Sep 6.
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