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関連論文:
img  43:  Improvement of quality of life in patients surgically treated for asymptomatic unruptured intracranial aneurysms.
 
著者: Shigeo Yamashiro, Toru Nishi, Kazunari Koga, Tomoaki Goto, Masatomo Kaji, Daisuke Muta, Jun-ichi Kuratsu, Shodo Fujioka
雑誌名: J Neurol Neurosurg Psychiatry. 2007 May;78(5):497-500. doi: 10.1136/jnnp.2006.098871. Epub 2006 Dec 18.
Abstract/Text OBJECTIVE: To compare the preoperative and postoperative health-related quality of life (QOL) and psychological state of patients with asymptomatic unruptured intracranial aneurysms (ICAs) who underwent elective surgery.
METHODS: Out of 67 patients who underwent neck clipping of ICAs, we assessed the QOL of 61 patients using Short Form-36 (SF-36); their psychological state was rated on the Hospital Anxiety and Depression Scale (HADS) before, 3 months, and 1 and 3 years after treatment.
RESULTS: The preoperative mean scores for each of the eight SF-36 domains except bodily pain were significantly lower in the study population than in the reference population. 14 (20.9%) patients experienced surgical complications defined as neurological deterioration and/or abnormal CT findings within 30 days of the operation. Despite some complications, the QOL of all operated patients returned to the mean level of the reference population 3 years after treatment. At 3 months after surgery, the scores for psychosocial activities and general health perception were transiently below the preoperative levels. According to the HADS, the patients experienced mild anxiety before the operation; it disappeared by the third postoperative month.
CONCLUSIONS: Preoperatively, patients with unruptured ICAs reported a significantly decreased QOL. It further declined transiently after elective surgery, but it returned to the mean level recorded for the reference population within 3 years. Our findings suggest that these patients derived significant QOL benefits from their surgery. Hence subjective QOL issues should be considered in deciding whether treatment-related risks and their natural history, such as their potential rupture, warrant surgery of asymptomatic unruptured ICAs.

PMID 17178825  J Neurol Neurosurg Psychiatry. 2007 May;78(5):497-500. doi: 10.1136/jnnp.2006.098871. Epub 2006 Dec 18.
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