各薬剤のM/P比、pKaおよびタンパク結合率
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母親の血中薬物曝露量（AUC）と乳汁中薬物曝露量（AUC）の比を乳汁／血漿薬物濃度比（milk-to-plasma drug concentration ratio、M/P比)といい、薬剤の母乳への移行性を示す指標として使用される。
出典
1:
Prediction of milk/plasma concentration ratio of drugs.
著者:
Line Alleslev Larsen, Shinya Ito, Gideon Koren
雑誌名:
Ann Pharmacother. 2003 Sep;37(9):1299-306. doi: 10.1345/aph.1C379.
Abstract/Text
OBJECTIVE:
The milk to plasma (m/p) concentration ratio of drugs is used to estimate the amount of drug offered to the suckling infant. Published literature was reviewed to identify drugs for which sufficient data exist for calculation of m/p ratio and to examine whether the existing empiric data agree with the published method of Atkinson for mathematical prediction of m/p ratios based on physiochemical characteristics.
METHODS:
Using a comprehensive reference text, we identified studies reporting sufficient data to calculate m/p ratio based on the AUC for milk and plasma. Subsequently, we calculated the m/p ratio with Atkinson's formula based on pKa, lipophilicity, and protein binding. We then correlated the empiric versus predicted (calculated) m/p ratios.
RESULTS:
Of 192 drugs of which at least some data on milk accumulation have been published, there were sufficient data to quantify m/p ratios for only 69 medications (78 studies). There was no significant correlation between the empiric m/p ratios and the predicted values using the Atkinson's model.
CONCLUSIONS:
Reliable data on m/p concentration ratios exist for few medications. Presently, there is no appropriate model to predict milk concentrations of drugs in humans.
Ann Pharmacother. 2003 Sep;37(9):1299-30･･･
