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小児直腸脱の治療方針

小児直腸脱の基本治療は保存治療である。
出典
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1: Management of rectal prolapse in children.
著者: B Antao, V Bradley, J P Roberts, R Shawis
雑誌名: Dis Colon Rectum. 2005 Aug;48(8):1620-5. doi: 10.1007/s10350-005-0074-0.
Abstract/Text: PURPOSE: Rectal prolapse in children is not uncommon and usually is a self-limiting condition in infancy. Most cases respond to conservative management; however, surgery is occasionally required in cases that are intractable to conservative treatment. This study was designed to analyze the outcomes of rectal prolapse in children and to propose a pathway for the management of these cases in children.
METHODS: A retrospective analysis of all cases of rectal prolapse referred to our surgical unit during a period of five years was performed. End point was recurrence of prolapse requiring manual reduction under sedation or an anesthetic. Results are presented as median (range) and statistical analysis was performed using chi-squared test; P < 0.05 was considered significant.
RESULTS: A total of 49 children (25 males) presented with symptoms of rectal prolapse at a median age of 2.6 years (range, 4 months -10.6 years). All children received an initial period of conservative treatment with watchful expectancy and/or laxatives. Twenty-five patients were managed conservatively without any additional procedures (Group A), and 24 patients had one or more interventions, such as injection sclerotherapy, Thiersch procedure, anal stretch, banding of prolapse, and rectopexy (Group B). Management of rectal prolapse was successful with no recurrences in 24 patients (96 percent) in Group A vs. 15 patients (63 percent) in Group B at a median follow-up period of 14 (range, 2-96) months. An underlying condition was found in 84 percent of patients in Group A vs. 54 percent in Group B (P = 0.024). The age at presentation was younger than four years in 88 percent of patients in Group A vs. 58 percent in Group B (P = 0.019).
CONCLUSIONS: Rectal prolapse in children does respond to conservative management. A decision to operate is based on age of patient, duration of conservative management, and frequency of recurrent prolapse (>2 episodes requiring manual reduction) along with symptoms of pain, rectal bleeding, and perianal excoriation because of recurrent prolapse. Those cases presenting younger than four years of age and with an associated condition have a better prognosis. The authors propose an algorithm for the management of rectal prolapse in children.
Dis Colon Rectum. 2005 Aug;48(8):1620-5. doi: 10.1007/s10350-005-0074-...

直腸脱の病態

完全直腸脱の誘因
出典
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1: 著者提供

小児直腸脱病因

病因が成人と異なり、解剖学的見地から仙骨の直立化、S状結腸の固定不良、直腸粘膜の筋層に対する固定不良、Houston弁の消失などが、関与すると考えられている。
出典
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1: 著者提供

完全直腸脱と不完全直腸脱の鑑別

同心円状の粘膜ひだを有する脱出腸管を確認すれば完全直腸脱、粘膜面の外見が放射状の溝を呈するならば不完全直腸脱と診断する。
a:完全直腸脱 同心円状のひだを持ち、数cm以上にわたり全層性に脱出する。
b:不完全直腸脱 粘膜のひだが同心円状でなく放射状であり、脱出の程度も軽度である。内痔核や粘膜脱症候群(MPS)など、鑑別が必要である。
出典
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1: a:Ferri, Fred F:Ferri's Clinical Advisor 2020. Rectal Prolapse, FIG.E1. Elsevier, 2020
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2: b:Goldman, Lee, MD:Goldman-Cecil Medicine, 26th Edition. 136.Diseases of the Rectum and Anus, FIGURE 136-6. Elsevier, 2020

MPSと病理組織所見

生検にて、間質における平滑筋・線維組織の増生(fibromuscular obliteration)が、MPSの特徴的所見として認められる。MPSを疑う場合、検体提出時のコメントに線維筋症(fibromuscular obliteration)の有無を確認してもらうよう記載することが大切である。
出典
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1: Mark Feldman, Lawrence Friedman, Lawrence Brandt: Sleisenger and Fordtran's Gastrointestinal and Liver Disease, 10th ed. 128. Other Diseases of the Colon and Rectum, FIGURE 128-21. Saunders, 2016

完全直腸脱の分類

Altemeir分類とTuttle分類がある。
 
参考文献:今充ほか 直腸脱の分類と発生メカニズム.日本大腸肛門病会誌1982;35:454.
出典
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1: 著者提供

完全直腸脱の代表的手術

低侵襲を特徴とする会陰アプローチと、再発率の低い経腹的アプローチがある。
出典
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1: 梅枝 覚:直腸脱の診断と治療.臨床外科 2008;63(11):329-338. より作成

直腸脱の主な術式と再発率

経腹的rectopexyは会陰アプローチと比較して再発率が低い。
出典
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1: Rectal prolapse: a historical perspective.
Curr Probl Surg. 2009 Aug;46(8):602-716. doi: 10.1067/j.cpsurg.2009.03.006.

Thiersch法

肛門管周囲にナイロン糸などを留置して肛門管を縫縮させる。
 
参考文献:Corman ML, Allison SI, Kuehne JP: Handbook of Colon and Rectal Surgery. Lippincott Williams & Wilkins, 2001.
出典
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Gant-Miwa法

脱出する直腸粘膜を縫縮し還納する。
出典
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Delorme法

a:脱出直腸の粘膜を環周切離する
b:直腸粘膜を筋層から分離する
c:直腸の固有筋層を縫縮する
d:縫縮された筋層を粘膜で被覆する
出典
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1: 編集部作成

Altemeier法

会陰式直腸・S状結腸切除術。
a:脱出する直腸壁を1層切離する
b:前壁の肛門挙筋を縫縮する
c:余剰直腸を切離する
d:口側結腸と肛門を吻合する
出典
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1: 編集部作成

PPH法

環状縫合器を用いた直腸脱手術:オリジナルのPPH法に準じて、直腸粘膜を2周にわたり環状縫合行い、より多くの余剰直腸粘膜を環状切除する。
出典
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1: 編集部作成

Ripstein法

a:Ripstein法(1963)、グラフトを膀胱から仙骨にわたり広く固定したうえで、直腸に巻きつけて固定した。
b:Ripstein法(1965)、テフロン性のグラフトを直腸に巻き、直腸後方で仙骨に固定した。
出典
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Wells法

ポリビニルアルコール性のメッシュを用いた直腸固定術(Well法)。メッシュは仙骨に固定し、直腸はトンネル状に包む(a)、あるいは直腸壁に縫合固定する(b)。
出典
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腹腔鏡下のventral rectopexy

出典
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1: 編集部作成

排便造影(defecography)

a:安静時  b:収縮時(完全直腸脱を認める)
出典
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1: 著者提供

腸管通過時間

結腸通過検査:腹部のX線画像。この便秘患者は、120時間前に20個の不活性リング型マーカーを、72時間前に20個のキューブ型マーカーを摂取した。大半のマーカーが腸管内に残存していることから、全腸通過時間の遅延が示唆される。
出典
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1: Cameron, Andrew M.:Current Surgical Therapy, 13th Edition. Surgical Management of Constipation, FIG.1. Elsevier, 2020

成人直腸脱の治療方針

完全直腸脱の場合、主に脱出の程度により術式が決められる。
出典
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1: 著者提供

再発直腸脱の治療方針

根治術後の再発に対しては、腸管切除を伴う、あるいは直腸固定による修復術が検討される。
出典
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1: 著者提供

小児直腸脱の治療方針

小児直腸脱の基本治療は保存治療である。
出典
imgimg
1: Management of rectal prolapse in children.
著者: B Antao, V Bradley, J P Roberts, R Shawis
雑誌名: Dis Colon Rectum. 2005 Aug;48(8):1620-5. doi: 10.1007/s10350-005-0074-0.
Abstract/Text: PURPOSE: Rectal prolapse in children is not uncommon and usually is a self-limiting condition in infancy. Most cases respond to conservative management; however, surgery is occasionally required in cases that are intractable to conservative treatment. This study was designed to analyze the outcomes of rectal prolapse in children and to propose a pathway for the management of these cases in children.
METHODS: A retrospective analysis of all cases of rectal prolapse referred to our surgical unit during a period of five years was performed. End point was recurrence of prolapse requiring manual reduction under sedation or an anesthetic. Results are presented as median (range) and statistical analysis was performed using chi-squared test; P < 0.05 was considered significant.
RESULTS: A total of 49 children (25 males) presented with symptoms of rectal prolapse at a median age of 2.6 years (range, 4 months -10.6 years). All children received an initial period of conservative treatment with watchful expectancy and/or laxatives. Twenty-five patients were managed conservatively without any additional procedures (Group A), and 24 patients had one or more interventions, such as injection sclerotherapy, Thiersch procedure, anal stretch, banding of prolapse, and rectopexy (Group B). Management of rectal prolapse was successful with no recurrences in 24 patients (96 percent) in Group A vs. 15 patients (63 percent) in Group B at a median follow-up period of 14 (range, 2-96) months. An underlying condition was found in 84 percent of patients in Group A vs. 54 percent in Group B (P = 0.024). The age at presentation was younger than four years in 88 percent of patients in Group A vs. 58 percent in Group B (P = 0.019).
CONCLUSIONS: Rectal prolapse in children does respond to conservative management. A decision to operate is based on age of patient, duration of conservative management, and frequency of recurrent prolapse (>2 episodes requiring manual reduction) along with symptoms of pain, rectal bleeding, and perianal excoriation because of recurrent prolapse. Those cases presenting younger than four years of age and with an associated condition have a better prognosis. The authors propose an algorithm for the management of rectal prolapse in children.
Dis Colon Rectum. 2005 Aug;48(8):1620-5. doi: 10.1007/s10350-005-0074-...

直腸脱の病態

完全直腸脱の誘因
出典
img
1: 著者提供