Now processing ... 
 Now searching ... 
 Now loading ... 

手足口病診察のアルゴリズム

出典
img
1: 著者提供

エンテロウイルス感染症の病態

エンテロウイルス感染症の病態とエンテロウイルスの血清型との間には関連がある。手足口病には、エンテロウイルス71とコクサッキーウイルスA16やA6が、ヘルパンギーナにはコクサッキーウイルスA群が関与する場合が多い。
出典
img
1: 細矢光亮(岡部信彦):小児感染症学: 診断と治療社, 2007; 446.

エンテロウイルス71型の遺伝子系統解析(B亜群)

エンテロウイルス71型をVP4遺伝子領域の塩基配列を決定し系統解析した。オレンジで示した急性脳炎症例から分離されたウイルスは、B-3とB-4亜群に集積した。
出典
imgimg
1: Genetic diversity of enterovirus 71 associated with hand, foot and mouth disease epidemics in Japan from 1983 to 2003.
著者: Hosoya M, Kawasaki Y, Sato M, Honzumi K, Kato A, Hiroshima T, Ishiko H, Suzuki H.
雑誌名: Pediatr Infect Dis J. 2006 Aug;25(8):691-4. doi: 10.1097/01.inf.0000227959.89339.c3.
Abstract/Text: BACKGROUND: Enterovirus 71 (EV71) is one of the major etiologic agents of hand, foot and mouth disease (HFMD). The surveillance data indicate that EV71 infection follows an epidemic mode of transmission, causing large outbreaks and then becoming quiescent for a few years.
METHODS: We investigated the genetic diversity of a total of 121 EV71 strains isolated from patients with HFMD in Fukushima, Japan, from 1983 to 2003 and compared their genetic relation with the 164 EV71 strains isolated in the world using phylogenetic analysis based on the VP4 sequence.
RESULTS: We observed EV71-related HFMD outbreaks in Fukushima in 1984, 1987, 1990, 1993, 1997, 2000 and 2003. Phylogenetic reconstruction of EV71 strains isolated in Fukushima demonstrated 8 genetically distinct clusters, including 6 subgroups previously designated as B-1, B-2 and 3, B-4, C-1, C-2, and C-3 and 2 subgroups newly designated as B-5 and C-4. Additional 2 indistinct clusters belonged to genogroup C and were named C-U1 and C-U2. Of those subgroups, B-1, C-U1, C-U2, C-2, B4, and C-4 and B-5 dominantly related to epidemics that occurred in the years 1984, 1987 and 1990, 1993, 1997, 2000 and 2003, respectively. EV71 strains derived from each outbreak in Fukushima formed a single cluster with those isolated during almost the same time period in other area of Japan and in other countries.
CONCLUSIONS: Our results suggested that the repeated EV71 outbreaks might be the result of the worldwide transmission of the newly introduced genetically divergent EV71 strains.
Pediatr Infect Dis J. 2006 Aug;25(8):691-4. doi: 10.1097/01.inf.000022...

エンテロウイルス71型の遺伝子系統解析(C亜群)

エンテロウイルス71型をVP4遺伝子領域の塩基配列を決定し系統解析した。C亜群には急性脳炎症例はなかった。
出典
imgimg
1: Genetic diversity of enterovirus 71 associated with hand, foot and mouth disease epidemics in Japan from 1983 to 2003.
著者: Hosoya M, Kawasaki Y, Sato M, Honzumi K, Kato A, Hiroshima T, Ishiko H, Suzuki H.
雑誌名: Pediatr Infect Dis J. 2006 Aug;25(8):691-4. doi: 10.1097/01.inf.0000227959.89339.c3.
Abstract/Text: BACKGROUND: Enterovirus 71 (EV71) is one of the major etiologic agents of hand, foot and mouth disease (HFMD). The surveillance data indicate that EV71 infection follows an epidemic mode of transmission, causing large outbreaks and then becoming quiescent for a few years.
METHODS: We investigated the genetic diversity of a total of 121 EV71 strains isolated from patients with HFMD in Fukushima, Japan, from 1983 to 2003 and compared their genetic relation with the 164 EV71 strains isolated in the world using phylogenetic analysis based on the VP4 sequence.
RESULTS: We observed EV71-related HFMD outbreaks in Fukushima in 1984, 1987, 1990, 1993, 1997, 2000 and 2003. Phylogenetic reconstruction of EV71 strains isolated in Fukushima demonstrated 8 genetically distinct clusters, including 6 subgroups previously designated as B-1, B-2 and 3, B-4, C-1, C-2, and C-3 and 2 subgroups newly designated as B-5 and C-4. Additional 2 indistinct clusters belonged to genogroup C and were named C-U1 and C-U2. Of those subgroups, B-1, C-U1, C-U2, C-2, B4, and C-4 and B-5 dominantly related to epidemics that occurred in the years 1984, 1987 and 1990, 1993, 1997, 2000 and 2003, respectively. EV71 strains derived from each outbreak in Fukushima formed a single cluster with those isolated during almost the same time period in other area of Japan and in other countries.
CONCLUSIONS: Our results suggested that the repeated EV71 outbreaks might be the result of the worldwide transmission of the newly introduced genetically divergent EV71 strains.
Pediatr Infect Dis J. 2006 Aug;25(8):691-4. doi: 10.1097/01.inf.000022...

手足口病

手足口に水疱性発疹を認める。
出典
img
1: 著者提供

手足口病診察のアルゴリズム

出典
img
1: 著者提供

エンテロウイルス感染症の病態

エンテロウイルス感染症の病態とエンテロウイルスの血清型との間には関連がある。手足口病には、エンテロウイルス71とコクサッキーウイルスA16やA6が、ヘルパンギーナにはコクサッキーウイルスA群が関与する場合が多い。
出典
img
1: 細矢光亮(岡部信彦):小児感染症学: 診断と治療社, 2007; 446.