アレルギー性気管支肺アスペルギルス症診断基準（Rosenberg）

一次基準の1～6を満たせば疑い濃厚例、すべて満たせば確診例となる。
出典
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1: Clinical and immunologic criteria for the diagnosis of allergic bronchopulmonary aspergillosis.
著者: M Rosenberg, R Patterson, R Mintzer, B J Cooper, M Roberts, K E Harris
雑誌名: Ann Intern Med. 1977 Apr;86(4):405-14.
Abstract/Text: Clinical and immunologic characteristics are reported in a series of 20 patients with allergic bronchopulmonary aspergillosis seen by physicians in one consulting service during a period of 9 years. Seventeen of these patients have been identified in the past 2 years, reflecting the increasing recognition of the entity. Fifteen of the 20 patients are believed to have proven diagnoses; the other five are strongly suspected. Asthma, pulmonary infiltrates, and eosinophilia are the usual presenting symptoms. Serum immunoglobulin E was markedly elevated in all patients, and serum immunoglobulin D was normal in four out of five patients sampled. Bronchograms were abnormal in all cases in which they could be done. Lymphocyte transformation may be present in some cases but is not a diagnostic feature. The average age at time of diagnosis was 25.5 years, and seven of the 15 proven patients were 20 or younger.
Ann Intern Med. 1977 Apr;86(4):405-14.

PattersonのABPAの病期と診断基準

この診断基準では、中枢性気管支拡張症が出現しない時期をABPA-SとしてI期の前に分類し、早期発見、早期治療の必要性を唱えている。
ABPA：アレルギー性気管支肺アスペルギルス症
Ig：Immunoglobulin

GreenbergerのABPA診断基準

Rosenbergの基準を満たさない非典型例も多い。この診断基準では気管支拡張に至っていないABPA-Sを早期発見し、注意深くフォローするのに適している。
出典
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1: Allergic bronchopulmonary aspergillosis.
著者: Paul A Greenberger
雑誌名: J Allergy Clin Immunol. 2002 Nov;110(5):685-92.
Abstract/Text: Allergic bronchopulmonary aspergillosis (ABPA) complicates asthma and cystic fibrosis. The survival factors in Aspergillus fumigatus that support saprophytic growth in bronchial mucus are not understood. Prednisone remains the most definitive treatment but need not be administered indefinitely. MHC II -restricted CD4(+) T( H)2 clones have been derived from patients with ABPA. The total serum IgE concentration is elevated sharply but is "nonspecific. " IgE serum isotypic antibodies to A fumigatus are useful in diagnosis; this is in contrast to the situation for patients with asthma without ABPA. High-resolution computed tomography of the chest demonstrates multiple areas of bronchiectasis in most patients with ABPA and is a useful radiologic tool. Some asthma control patients might have a few bronchiectatic airways, but not to the extent seen in or of the same character as those in ABPA. This review discusses clinical, radiologic, investigational, pathogenetic, and treatment issues of ABPA.
J Allergy Clin Immunol. 2002 Nov;110(5):685-92.

GreenbergerによるABPA初期治療

ABPAは再燃を繰り返すと致死的になり得る疾患であるため、急性増悪を予防し、また起きた場合には早期に診断・治療することが重要である。
出典
imgimg
1: Allergic bronchopulmonary aspergillosis.
著者: Paul A Greenberger
雑誌名: J Allergy Clin Immunol. 2002 Nov;110(5):685-92.
Abstract/Text: Allergic bronchopulmonary aspergillosis (ABPA) complicates asthma and cystic fibrosis. The survival factors in Aspergillus fumigatus that support saprophytic growth in bronchial mucus are not understood. Prednisone remains the most definitive treatment but need not be administered indefinitely. MHC II -restricted CD4(+) T( H)2 clones have been derived from patients with ABPA. The total serum IgE concentration is elevated sharply but is "nonspecific. " IgE serum isotypic antibodies to A fumigatus are useful in diagnosis; this is in contrast to the situation for patients with asthma without ABPA. High-resolution computed tomography of the chest demonstrates multiple areas of bronchiectasis in most patients with ABPA and is a useful radiologic tool. Some asthma control patients might have a few bronchiectatic airways, but not to the extent seen in or of the same character as those in ABPA. This review discusses clinical, radiologic, investigational, pathogenetic, and treatment issues of ABPA.
J Allergy Clin Immunol. 2002 Nov;110(5):685-92.