Systematic review: the epidemiology of eosinophilic oesophagitis in adults.
著者: R J Sealock, G Rendon, H B El-Serag 雑誌名: Aliment Pharmacol Ther. 2010 Sep;32(6):712-9. doi: 10.1111/j.1365-2036.2010.04411.x. Abstract/TextBACKGROUND: The epidemiology of eosinophilic oesophagitis (EoE) in adults remains unclear. AIM: To estimate the prevalence and incidence of EoE through a systematic review of published literature. METHODS: We conducted systematic literature searches in PubMed in September 2009. Studies were excluded if they contained any participants below 18 years of age, published in languages other than English, or had no exact reporting of prevalence or incidence rates. RESULTS: Nine studies fulfilled the criteria; one evaluated a population-based sample, one examined patients referred from a defined geographical region and seven studies examined the prevalence in a total of 6018 patients in clinic or hospital settings. The lowest prevalence was reported in population-based studies (4 and 0.23 per 1000), followed by studies of unselected patients (1.0%, 6.5%) and highest in the other five clinic/hospital based studies (2.2-48.2%). Men were more affected in seven of eight studies (64.5-100%). The sample size weighted average prevalence from the population-based studies was 0.03%. For studies evaluating symptomatic patients, it was 2.8%. CONCLUSIONS: The prevalence of EoE in adults varies considerably based on the study sampling frame: high in dysphagia patients, quite low in population-based studies and intermediate among unselected endoscopy patients.
Eosinophilic esophagitis investigated by upper gastrointestinal endoscopy in Japanese patients.
著者: Hirofumi Fujishiro, Yuji Amano, Yoshinori Kushiyama, Shunji Ishihara, Yoshikazu Kinoshita 雑誌名: J Gastroenterol. 2011 Sep;46(9):1142-4. doi: 10.1007/s00535-011-0435-5. Epub 2011 Jul 13. Abstract/TextBACKGROUND: The prevalence of eosinophilic esophagitis (EE) is increasing rapidly in Western countries. Several case series of EE have also been reported in Japan. However, the prevalence of EE in Japanese patients as investigated by upper gastrointestinal endoscopy is unknown. Therefore, we carried out a prospective multicenter study to address this issue. METHODS: From July to December 2010, 23,346 patients who had undergone routine upper gastrointestinal endoscopy in 17 institutions were enrolled. In patients with symptoms suggesting EE, such as dysphasia, food impaction, and heartburn, and/or in patients in whom endoscopic findings suggested pathology, esophageal biopsy samples were collected, and the numbers of eosinophils in the squamous epithelium were counted. RESULTS: During the study period of 6 months, 4 patients were endoscopically and histologically diagnosed with EE. The prevalence of EE was calculated to be 17.1/100,000. CONCLUSION: The prevalence of EE in Japanese patients by upper gastrointestinal endoscopy has now been documented.
Systematic review: Eosinophilic esophagitis in Asian countries.
著者: Yoshikazu Kinoshita, Norihisa Ishimura, Naoki Oshima, Shunji Ishihara 雑誌名: World J Gastroenterol. 2015 Jul 21;21(27):8433-40. doi: 10.3748/wjg.v21.i27.8433. Abstract/TextAIM: To investigate the prevalence and the clinical characteristics of Asian patients with eosinophilic esophagitis. METHODS: We conducted a systematic search of the PubMed and Web of Science databases for original studies, case series, and individual case reports of eosinophilic esophagitis in Asian countries published from January 1980 to January 2015. We found 66 and 80 articles in the PubMed and Web of Science databases, respectively; 24 duplicate articles were removed. After excluding animal studies, articles not written in English, and meeting abstracts, 25 articles containing 217 patients were selected for analysis. RESULTS: Sample size-weighted mean values were determined for all pooled prevalence data and clinical characteristics. The mean age of the adult patients with eosinophilic esophagitis was approximately 50 years, and 73% of these patients were male. They frequently presented with allergic diseases including bronchial asthma, allergic rhinitis, food allergy, and atopic dermatitis. Bronchial asthma was the most frequent comorbid allergic disease, occurring in 24% of patients with eosinophilic esophagitis. Dysphagia was the primary symptom reported; 44% of the patients complained of dysphagia. Although laboratory blood tests are not adequately sensitive for an accurate diagnosis of eosinophilic esophagitis, endoscopic examinations revealed abnormal findings typical of this disease, including longitudinal furrows and concentric rings, in 82% of the cases. One-third of the cases responded to proton pump inhibitor administration. CONCLUSION: The characteristics of eosinophilic esophagitis in Asian patients were similar to those reported in Western patients, indicating that this disease displays a similar pathogenesis between Western and Asian patients.
PMID 26217096 World J Gastroenterol. 2015 Jul 21;21(27):8433-40. doi:･･･
病態・疫学・診察
