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著者: Yoko Inou, Tetsuo Nakayama, Naoko Yoshida, Hajime Uejima, Kenji Yuri, Makoto Kamada, Takuji Kumagai, Hiroshi Sakiyama, Akiko Miyata, Hitoshi Ochiai, Toshiaki Ihara, Teruo Okafuji, Takao Okafuji, Takao Nagai, Eitaro Suzuki, Kunihisa Shimomura, Yuhei Ito, Chiaki Miyazaki
雑誌名: J Med Virol. 2004 May;73(1):97-104. doi: 10.1002/jmv.20065.
Abstract/Text
We isolated 872 strains of mumps virus from naso-pharyngeal secretions in seven different districts of Japan from January 2000 to July 2001. Among them, 57 strains were geno-typed by nucleotide sequencing in part of the hemagglutinin-neuraminidase (HN) and small hydrophobic (SH) protein regions. Four different genotypes (B, G, K, and L) of mumps virus were co-circulating in Japan and the distribution of genotypes varied in geographically different districts. Two new clusters designated as genotypes K and L had more than 7% nucleotide variation in the SH gene. Among the 57 strains, 11 were classified as B, 35 as G, three as K, and eight as L, which was mainly isolated in Tokyo. We also examined 104 stains isolated in a clinic in Mie prefecture from 1993 to 2003. Genotype B was the indigenous strain and genotype K was introduced in 1994. Genotypes B and K co-circulated in the 1990s and were replaced by genotype G in 2000. There was no significant change in neutralizing test antibody titers against genotypes B, G, K, and L using seven post-vaccination sera with Hoshino strain (genotype B) and these four genotypes had a different antigenicity from genotype A. We should continue to watch on mumps virus molecular epidemiology.
Copyright 2004 Wiley-Liss, Inc.
PMID 15042655 J Med Virol. 2004 May;73(1):97-104. doi: 10.1002/jmv.20065.
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