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著者: Yen A, Fearneyhough P, Raimer SS, Hudnall SD.
雑誌名: J Am Acad Dermatol. 1997 Feb;36(2 Pt 2):342-6. doi: 10.1016/s0190-9622(97)80413-6.
Abstract/Text
The clinical and pathologic findings of Kikuchi's histiocytic necrotizing lymphadenitis may mimic those of malignant lymphoma. We describe a 6-year-old boy with generalized lymphadenopathy, spiking fever, chills, myalgias, malaise, and erythematous, crusted papules. Although cutaneous manifestations have been noted in 16% to 40% of patients with histiocytic necrotizing lymphadenitis, only three publications described skin lesions. The skin lesions and affected lymph nodes revealed histiocytic aggregates, atypical lymphoid cells, karyorrhectic debris, and patchy necrosis. Spontaneous resolution occurred in 2 months. Results of serologic studies, Epstein-Barr virus (EBV) latent membrane protein immunoperoxidase staining, EBER-1 RNA in-situ hybridization, and EBV EBNA-1 DNA polymerase chain reaction implicate EBV as the causative agent.
PMID 9039215 J Am Acad Dermatol. 1997 Feb;36(2 Pt 2):342-6. doi: 10.1016/s0190-9622(97)80413-6.
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