今日の臨床サポート 今日の臨床サポート
関連論文:
img  3:  Movement disorders induced by antipsychotic drugs: implications of the CATIE schizophrenia trial.
 
著者: Stanley N Caroff, Irene Hurford, Janice Lybrand, E Cabrina Campbell
雑誌名: Neurol Clin. 2011 Feb;29(1):127-48, viii. doi: 10.1016/j.ncl.2010.10.002.
Abstract/Text Drug-induced movement disorders have dramatically declined with the widespread use of second-generation antipsychotics, but remain important in clinical practice and for understanding antipsychotic pharmacology. The diagnosis and management of dystonia, parkinsonism, akathisia, catatonia, neuroleptic malignant syndrome, and tardive dyskinesia are reviewed in relation to the decreased liability of the second-generation antipsychotics contrasted with evidence from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Schizophrenia Trial. Data from the CATIE trial imply that advantages of second-generation antipsychotics in significantly reducing extrapyramidal side effects compared with haloperidol may be diminished when compared with modest doses of lower-potency first-generation drugs.

Published by Elsevier Inc.
PMID 21172575  Neurol Clin. 2011 Feb;29(1):127-48, viii. doi: 10.1016/j.ncl.2010.10.002.

遅発性ジスキネジア

戻る