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著者: Naoyoshi Onoda, Iwao Sugitani, Ken-Ichi Ito, Akifumi Suzuki, Takuya Higashiyama, Tatsuya Fukumori, Nobuyasu Suganuma, Katsuhiko Masudo, Hirotaka Nakayama, Atsuhiko Uno, Katsunari Yane, Seiichi Yoshimoto, Aya Ebina, Yukari Kawasaki, Shigeto Maeda, Manabu Iwadate, Shinichi Suzuki
雑誌名: Cancers (Basel). 2020 Feb 27;12(3). doi: 10.3390/cancers12030552. Epub 2020 Feb 27.
Abstract/Text
BACKGROUND: The tumor-node-metastasis (TNM) classification system to categorized anaplastic thyroid cancer (ATC) was revised.
METHODS: The revised system was evaluated using a large database of ATC patients.
RESULTS: A total of 757 patients were analyzed. The proportion and median overall survival values (OS: months) for each T category were T1 (n = 8, 1.1%, 12.5), T2 (n = 43, 5.7%, 10.9), T3a (n = 117, 15.5%, 5.7), T3b (n = 438, 57.9%, 3.9), and T4 (n = 151, 19.9%, 5.0). The OS of the N0 and N1 patients were 5.9 and 4.3, respectively (log-rank p < 0.01). Sixty-three (58.3%) patients migrated from stage IV A to IV B by revision based on the existence of nodal involvement and 422 patients (55.7%) were stratified into stage IV B, without a worsening of their OS (6.1), leaving 45 patients (5.9%) in stage IV A with fair OS (15.8). The hazard ratios for the survival of the patients of stage IV B compared to stage IV A increased from 1.1 to 2.1 by the revision. No change was made for stage IV C (n = 290, 38.8%, 2.8).
CONCLUSION: The revised TNM system clearly indicated the prognoses of ATC patients by extracting rare patients with fair prognoses as having stage IV A disease and categorized many heterogeneous patients in stage IV B.
PMID 32120853 Cancers (Basel). 2020 Feb 27;12(3). doi: 10.3390/cancers12030552. Epub 2020 Feb 27.
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